Colicin E7
From Proteopedia
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| - | Colicin E7 has an endonuclease domain that degrades the DNA of the targeted cell. This structure shows this domain. | + | Colicin E7 has an endonuclease domain that degrades the DNA of the targeted cell. This structure shows this domain bound to a DNA octamer <ref> PMID: 14962381 </ref>. |
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| + | ==References== | ||
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| + | <references/> | ||
Revision as of 16:57, 31 January 2011
Colicin E3 is a type of Colicin, a bacteriocin made by E. coli which acts against other nearby E. coli to kill them with its DNase activity; it digests the cell's genome in specific locations, ultimately leading to the death of the cell.
Contents |
Synthesis and release
After synthesis inside the E. coli cell, the colicin binds its immunity protein, Im7, to its nuclease domain, to prevent the host cell from being killed by its activity. This immunity protein is released only on binding to the outer membrane of the target cell.
Mechanism of uptake
Killing Activities
Colicin E7 has an endonuclease domain that degrades the DNA of the targeted cell. This structure shows this domain bound to a DNA octamer [1].
References
- ↑ Hsia KC, Chak KF, Liang PH, Cheng YS, Ku WY, Yuan HS. DNA binding and degradation by the HNH protein ColE7. Structure. 2004 Feb;12(2):205-14. PMID:14962381 doi:10.1016/j.str.2004.01.004
