2ot8
From Proteopedia
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==Overview== | ==Overview== | ||
| - | Kapbeta2 (also called transportin) recognizes PY nuclear localization | + | Kapbeta2 (also called transportin) recognizes PY nuclear localization signal (NLS), a new class of NLS with a R/H/Kx((2-5))PY motif. Here we show that Kapbeta2 complexes containing hydrophobic and basic PY-NLSs, as classified by the composition of an additional N-terminal motif, converge in structure only at consensus motifs, which explains ligand diversity. On the basis of these data and complementary biochemical analyses, we designed a Kapbeta2-specific nuclear import inhibitor, M9M. |
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| + | ==Disease== | ||
| + | Known disease associated with this structure: Deafness, mitochondrial, modifier of OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=610230 610230]] | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| - | [[Category: Cansizoglu, A | + | [[Category: Cansizoglu, A E.]] |
| - | [[Category: Chook, Y | + | [[Category: Chook, Y M.]] |
[[Category: heat repeat]] | [[Category: heat repeat]] | ||
[[Category: karyopherin]] | [[Category: karyopherin]] | ||
[[Category: nuclear import complex]] | [[Category: nuclear import complex]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:22:15 2008'' |
Revision as of 16:22, 21 February 2008
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Karyopherin Beta2/Transportin-hnRNPM NLS Complex
Contents |
Overview
Kapbeta2 (also called transportin) recognizes PY nuclear localization signal (NLS), a new class of NLS with a R/H/Kx((2-5))PY motif. Here we show that Kapbeta2 complexes containing hydrophobic and basic PY-NLSs, as classified by the composition of an additional N-terminal motif, converge in structure only at consensus motifs, which explains ligand diversity. On the basis of these data and complementary biochemical analyses, we designed a Kapbeta2-specific nuclear import inhibitor, M9M.
Disease
Known disease associated with this structure: Deafness, mitochondrial, modifier of OMIM:[610230]
About this Structure
2OT8 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure-based design of a pathway-specific nuclear import inhibitor., Cansizoglu AE, Lee BJ, Zhang ZC, Fontoura BM, Chook YM, Nat Struct Mol Biol. 2007 May;14(5):452-4. Epub 2007 Apr 15. PMID:17435768
Page seeded by OCA on Thu Feb 21 18:22:15 2008
