3pnl
From Proteopedia
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{{STRUCTURE_3pnl| PDB=3pnl | SCENE= }} | {{STRUCTURE_3pnl| PDB=3pnl | SCENE= }} | ||
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===Crystal Structure of E.coli Dha kinase DhaK-DhaL complex=== | ===Crystal Structure of E.coli Dha kinase DhaK-DhaL complex=== | ||
| + | {{ABSTRACT_PUBMED_21209328}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/DHAK_ECOLI DHAK_ECOLI]] Dihydroxyacetone binding subunit of the dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone. Binds covalently dihydroxyacetone in hemiaminal linkage. Acts also as a corepressor of DhaR by binding to its sensor domain, in the absence of dihydroxyacetone. [[http://www.uniprot.org/uniprot/DHAL_ECOLI DHAL_ECOLI]] ADP-binding subunit of the dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone. DhaL-ADP receives a phosphoryl group from DhaM and transmits it to dihydroxyacetone. DhaL-ADP acts also as a coactivator by binding to the sensor domain of DhaR. DhaL-ATP is inactive. | |
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==About this Structure== | ==About this Structure== | ||
| - | [[3pnl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli | + | [[3pnl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PNL OCA]. |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:021209328</ref><references group="xtra"/><references/> |
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
| - | [[Category: Escherichia coli k-12]] | ||
[[Category: BSGI, Montreal-Kingston Bacterial Structural Genomics Initiative.]] | [[Category: BSGI, Montreal-Kingston Bacterial Structural Genomics Initiative.]] | ||
[[Category: Cygler, M.]] | [[Category: Cygler, M.]] | ||
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[[Category: McDonald, L.]] | [[Category: McDonald, L.]] | ||
[[Category: Shi, R.]] | [[Category: Shi, R.]] | ||
| + | [[Category: Bsgi]] | ||
| + | [[Category: Dha kinase]] | ||
| + | [[Category: Montreal-kingston bacterial structural genomics initiative]] | ||
| + | [[Category: Structural genomic]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 08:17, 8 May 2013
Contents |
Crystal Structure of E.coli Dha kinase DhaK-DhaL complex
Template:ABSTRACT PUBMED 21209328
Function
[DHAK_ECOLI] Dihydroxyacetone binding subunit of the dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone. Binds covalently dihydroxyacetone in hemiaminal linkage. Acts also as a corepressor of DhaR by binding to its sensor domain, in the absence of dihydroxyacetone. [DHAL_ECOLI] ADP-binding subunit of the dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone. DhaL-ADP receives a phosphoryl group from DhaM and transmits it to dihydroxyacetone. DhaL-ADP acts also as a coactivator by binding to the sensor domain of DhaR. DhaL-ATP is inactive.
About this Structure
3pnl is a 2 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
- Shi R, McDonald L, Cui Q, Matte A, Cygler M, Ekiel I. Structural and mechanistic insight into covalent substrate binding by Escherichia coli dihydroxyacetone kinase. Proc Natl Acad Sci U S A. 2011 Jan 5. PMID:21209328 doi:10.1073/pnas.1012596108
