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==Introduction== | ==Introduction== | ||
| - | Factor XIa is | + | Factor XIa is unique protease derived from the activation of the coagulation zymogen, factor XI. Factor XIa partcipates in the procoagulant response via contact activation pathway. Synthesized by the liver similar to most vitamin K-dependent coagulation proteins, the zymogen, factor XI circulates in plasma as a 160 kDa disulfide-linked homodimer in complex with high molecular weight kininogen (HK)(REF). Studies show that factor XI is a substrate for various plasma proteins such as factor XIIa, [[thrombin]], meizothrombin and factor XIa (via autoactivation). Proteolysis of the Arg369-Ile370 bond generates the active enzyme factor XIa which in turn cleaves its substrate factor factor IX to produce the serine protease factor IXa. |
{{STRUCTURE_3bg8 | PDB=3bg8 | SCENE= }} | {{STRUCTURE_3bg8 | PDB=3bg8 | SCENE= }} | ||
Revision as of 00:18, 20 February 2011
Contents |
Coagulation Factor XIa
Introduction
Factor XIa is unique protease derived from the activation of the coagulation zymogen, factor XI. Factor XIa partcipates in the procoagulant response via contact activation pathway. Synthesized by the liver similar to most vitamin K-dependent coagulation proteins, the zymogen, factor XI circulates in plasma as a 160 kDa disulfide-linked homodimer in complex with high molecular weight kininogen (HK)(REF). Studies show that factor XI is a substrate for various plasma proteins such as factor XIIa, thrombin, meizothrombin and factor XIa (via autoactivation). Proteolysis of the Arg369-Ile370 bond generates the active enzyme factor XIa which in turn cleaves its substrate factor factor IX to produce the serine protease factor IXa. Template:STRUCTURE 3bg8
