3k51

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[[Image:3k51.png|left|200px]]
 
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{{STRUCTURE_3k51| PDB=3k51 | SCENE= }}
{{STRUCTURE_3k51| PDB=3k51 | SCENE= }}
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===Crystal Structure of DcR3-TL1A complex===
===Crystal Structure of DcR3-TL1A complex===
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{{ABSTRACT_PUBMED_21300286}}
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==Function==
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[[http://www.uniprot.org/uniprot/TNF15_HUMAN TNF15_HUMAN]] Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis.<ref>PMID:9872942</ref> <ref>PMID:11923219</ref> <ref>PMID:11911831</ref> <ref>PMID:10597252</ref>
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{{ABSTRACT_PUBMED_21300286}}
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==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:21300286</ref><references group="xtra"/>
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<ref group="xtra">PMID:021300286</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Almo, S C.]]
[[Category: Almo, S C.]]
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[[Category: Yan, Q.]]
[[Category: Yan, Q.]]
[[Category: Zhan, C.]]
[[Category: Zhan, C.]]
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[[Category: Apoptosis]]
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[[Category: Cytokine]]
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[[Category: Dcr3]]
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[[Category: Decoy receptor]]
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[[Category: Disulfide bond]]
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[[Category: Glycoprotein]]
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[[Category: Immune system]]
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[[Category: Immunity]]
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[[Category: Membrane]]
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[[Category: Receptor]]
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[[Category: Secreted]]
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[[Category: Signal-anchor]]
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[[Category: Tl1a]]
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[[Category: Tnf]]
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[[Category: Tnfr]]
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[[Category: Transmembrane]]

Revision as of 02:17, 4 April 2013

Template:STRUCTURE 3k51

Contents

Crystal Structure of DcR3-TL1A complex

Template:ABSTRACT PUBMED 21300286

Function

[TNF15_HUMAN] Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis.[1] [2] [3] [4]

About this Structure

3k51 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Zhan C, Patskovsky Y, Yan Q, Li Z, Ramagopal U, Cheng H, Brenowitz M, Hui X, Nathenson SG, Almo SC. Decoy Strategies: The Structure of TL1A:DcR3 Complex. Structure. 2011 Feb 9;19(2):162-71. PMID:21300286 doi:10.1016/j.str.2010.12.004
  1. ↑ Zhai Y, Ni J, Jiang GW, Lu J, Xing L, Lincoln C, Carter KC, Janat F, Kozak D, Xu S, Rojas L, Aggarwal BB, Ruben S, Li LY, Gentz R, Yu GL. VEGI, a novel cytokine of the tumor necrosis factor family, is an angiogenesis inhibitor that suppresses the growth of colon carcinomas in vivo. FASEB J. 1999 Jan;13(1):181-9. PMID:9872942
  2. ↑ Chew LJ, Pan H, Yu J, Tian S, Huang WQ, Zhang JY, Pang S, Li LY. A novel secreted splice variant of vascular endothelial cell growth inhibitor. FASEB J. 2002 May;16(7):742-4. Epub 2002 Mar 26. PMID:11923219 doi:10.1096/fj.01-0757fje
  3. ↑ Migone TS, Zhang J, Luo X, Zhuang L, Chen C, Hu B, Hong JS, Perry JW, Chen SF, Zhou JX, Cho YH, Ullrich S, Kanakaraj P, Carrell J, Boyd E, Olsen HS, Hu G, Pukac L, Liu D, Ni J, Kim S, Gentz R, Feng P, Moore PA, Ruben SM, Wei P. TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator. Immunity. 2002 Mar;16(3):479-92. PMID:11911831
  4. ↑ Haridas V, Shrivastava A, Su J, Yu GL, Ni J, Liu D, Chen SF, Ni Y, Ruben SM, Gentz R, Aggarwal BB. VEGI, a new member of the TNF family activates nuclear factor-kappa B and c-Jun N-terminal kinase and modulates cell growth. Oncogene. 1999 Nov 11;18(47):6496-504. PMID:10597252 doi:10.1038/sj.onc.1203059

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