Sandbox Reserved 312
From Proteopedia
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{{STRUCTURE_2fbv| PDB=2fbv | SCENE= }} | {{STRUCTURE_2fbv| PDB=2fbv | SCENE= }} | ||
| - | Werner (WRN) protein is one of the five human RecQDNA helicases, which | + | Werner (WRN) protein is one of the five human RecQDNA helicases, which perform DNA replication, recombination, and repair. This enzyme has a helicases function (unwinding the DNA helix) and a nuclease function (degrading), which allows for deletion of mutation and proofreading. The WRN has a functional exonuclease domain located on the N-terminus. WRN protein protects human from cancer; as well as, premature aging. |
Revision as of 07:10, 3 March 2011
| This Sandbox is Reserved from January 10, 2010, through April 10, 2011 for use in BCMB 307-Proteins course taught by Andrea Gorrell at the University of Northern British Columbia, Prince George, BC, Canada. |
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| 2fbv, resolution 2.40Å () | |||||||||
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| Ligands: | |||||||||
| Gene: | WRN, RECQ3, RECQL2 (Homo sapiens) | ||||||||
| Related: | 2fbt, 2fbx, 2fby, 2fc0 | ||||||||
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| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Werner (WRN) protein is one of the five human RecQDNA helicases, which perform DNA replication, recombination, and repair. This enzyme has a helicases function (unwinding the DNA helix) and a nuclease function (degrading), which allows for deletion of mutation and proofreading. The WRN has a functional exonuclease domain located on the N-terminus. WRN protein protects human from cancer; as well as, premature aging.
Contents |
Function
Structure
WRN is a enzyme with both magnesium and ATP-dependent DNA-helicase activity with a 3'->5' exonuclease activity towards double-stranded DNA. Magnesium
Crystallization
Active Site
Substrate-Binding Site
Clinical significance
When the gene coding for WRN is mutated a autosomal recessive disorder causing rapid aging(osteoporosis, atherosclerosis and cancer). This is known as Werner syndrome which appears at puberty.
