2dz7
From Proteopedia
(New page: 200px<br /><applet load="2dz7" size="350" color="white" frame="true" align="right" spinBox="true" caption="2dz7, resolution 1.60Å" /> '''DNA Octaplex Formati...) |
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==Overview== | ==Overview== | ||
| - | The crystal structure of the tetragonal form of d(gcGAAAgc) has been | + | The crystal structure of the tetragonal form of d(gcGAAAgc) has been revised and reasonably refined including the disordered residues. The two DNA strands form a base-intercalated duplex, and the four duplexes are assembled according to the crystallographic 222 symmetry to form an octaplex. In the central region, the eight strands are associated by I-motif of double A-quartets. Furthermore, eight hydrated-magnesium cations link the four duplexes to support the octaplex formation. Based on these structural features, a proposal that folding of d(GAAA)n, found in the non-coding region of genomes, into an octaplex can induce slippage during replication to facilitate length polymorphism is presented. |
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | DNA octaplex formation with an I-motif of water-mediated A-quartets: reinterpretation of the crystal structure of d(GCGAAAGC)., Sato Y, Mitomi K, Sunami T, Kondo J, Takenaka A, J Biochem | + | DNA octaplex formation with an I-motif of water-mediated A-quartets: reinterpretation of the crystal structure of d(GCGAAAGC)., Sato Y, Mitomi K, Sunami T, Kondo J, Takenaka A, J Biochem. 2006 Dec;140(6):759-62. Epub 2006 Oct 24. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17062599 17062599] |
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Kondo, J.]] | [[Category: Kondo, J.]] | ||
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[[Category: vntr]] | [[Category: vntr]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:04:25 2008'' |
Revision as of 15:04, 21 February 2008
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DNA Octaplex Formation with an I-Motif of A-Quartets: The Revised Crystal Structure of d(GCGAAAGC)
Overview
The crystal structure of the tetragonal form of d(gcGAAAgc) has been revised and reasonably refined including the disordered residues. The two DNA strands form a base-intercalated duplex, and the four duplexes are assembled according to the crystallographic 222 symmetry to form an octaplex. In the central region, the eight strands are associated by I-motif of double A-quartets. Furthermore, eight hydrated-magnesium cations link the four duplexes to support the octaplex formation. Based on these structural features, a proposal that folding of d(GAAA)n, found in the non-coding region of genomes, into an octaplex can induce slippage during replication to facilitate length polymorphism is presented.
About this Structure
2DZ7 is a Protein complex structure of sequences from [1] with as ligand. Full crystallographic information is available from OCA.
Reference
DNA octaplex formation with an I-motif of water-mediated A-quartets: reinterpretation of the crystal structure of d(GCGAAAGC)., Sato Y, Mitomi K, Sunami T, Kondo J, Takenaka A, J Biochem. 2006 Dec;140(6):759-62. Epub 2006 Oct 24. PMID:17062599
Page seeded by OCA on Thu Feb 21 17:04:25 2008
Categories: Protein complex | Kondo, J. | Mitomi, K. | Sato, Y. | Sumani, T. | Takenaka, A. | MG | A-quartet | Dna octaplex | Non-coding dna | Vntr
