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2ewp

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Revision as of 05:47, 9 March 2011

Image:2ewp.png

Template:STRUCTURE 2ewp

Crystal structure of Estrogen Related Receptor-3 (ERR-gamma) ligand binding domaind with tamoxifen analog GSK5182

Template:ABSTRACT PUBMED 16307879

About this Structure

2ewp is a 5 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Chao EY, Collins JL, Gaillard S, Miller AB, Wang L, Orband-Miller LA, Nolte RT, McDonnell DP, Willson TM, Zuercher WJ. Structure-guided synthesis of tamoxifen analogs with improved selectivity for the orphan ERRgamma. Bioorg Med Chem Lett. 2006 Feb 15;16(4):821-4. Epub 2005 Nov 22. PMID:16307879 doi:10.1016/j.bmcl.2005.11.030