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Revision as of 07:38, 10 March 2011

Please do NOT make changes to this Sandbox. Sandboxes 30-60 are reserved for use by Biochemistry 410 & 412 at Messiah College taught by Dr. Hannah Tims during Fall 2012 and Spring 2013.

Contents 1 Methotrexate 1.1 History 1.2 Relevance 1.3 Structural Features 1.4 Mechanism of Action 1.4.1 Active Site 1.5 Pharmacokinetics 1.5.1 Drug Treatment 1.6 Drug Synthesis 1.7 Protein Interactions 1.8 References

Methotrexate

spinqualitylabelsall models methotrexate structure Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

INTRO

History

Relevance

spinqualitylabelsall models human DHFR with folate and NADPH Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Structural Features

Mechanism of Action

HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND FOLATE 2w3m

Active Site

< size='300'> Image:2011-03-10 0224.png

eig

spinqualitylabelsall models Insert caption here Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Pharmacokinetics

^[1].

Drug Treatment

Drug Synthesis

Protein Interactions

greenlinks

spinqualitylabelsall models Insert caption here Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

References

1. ↑ Voet, D., Voet, J. G., & Pratt, C. W. (2008). Fundamentals of biochemistry: life at the molecular level (3rd ed.). Hoboken, NJ: Wiley.