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Revision as of 06:04, 11 March 2011

This Sandbox is Reserved from January 10, 2010, through April 10, 2011 for use in BCMB 307-Proteins course taught by Andrea Gorrell at the University of Northern British Columbia, Prince George, BC, Canada.

To get started: Click the edit this page tab at the top. Save the page after each step, then edit it again. Click the 3D button (when editing, above the wikitext box) to insert Jmol. show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page. Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc. More help: Help:Editing

Contents 1 Aldose Reductase (2IKH) 2 Title 2.1 Sub Title 2.1.1 Sub Sub Title 3 Title 4 References

Aldose Reductase (2IKH)

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Wikipedia

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Policosanol, a well-defined mixture of very long chain primary alcohols that is available as a nutraceutical product, has been reported to lower blood cholesterol levels.^[1] In summary, this study provides the platform for further structure-guided design hypotheses of novel drug candidates with higher affinity and selectivity.^[2]

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References

1. ↑ Banerjee S, Ghoshal S, Porter TD. Activation of AMP-kinase by Policosanol Requires Peroxisomal Metabolism. Lipids. 2011 Feb 27. PMID:21359855 doi:10.1007/s11745-011-3540-6
2. ↑ Steuber H, Heine A, Klebe G. Structural and thermodynamic study on aldose reductase: nitro-substituted inhibitors with strong enthalpic binding contribution. J Mol Biol. 2007 May 4;368(3):618-38. Epub 2006 Dec 15. PMID:17368668 doi:10.1016/j.jmb.2006.12.004