Simvastatin Synthase
From Proteopedia
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| - | {{STRUCTURE_3hle | PDB=3hle | SCENE= }} | + | {{STRUCTURE_3hle | PDB=3hle | SCENE= }} ==Introduction== |
Simvastation synthase (LovD) is an enzyme isolatied from the natural product biosynthetic pathways of''Aspergillus terreus''. | Simvastation synthase (LovD) is an enzyme isolatied from the natural product biosynthetic pathways of''Aspergillus terreus''. | ||
Simvastatin Synthase is an acyltransferase that converts the inactive monacolin J acid (MJA) into the cholesterol-lowering lovastatin.[[Image:LovD copy.jpg]] | Simvastatin Synthase is an acyltransferase that converts the inactive monacolin J acid (MJA) into the cholesterol-lowering lovastatin.[[Image:LovD copy.jpg]] | ||
LovD can also synthesize the blockbuster drug simvastatin using MJA and a synthetic alpha-dimethylbutyryl thioester, albeit with suboptimal properties as a biocatalyst. | LovD can also synthesize the blockbuster drug simvastatin using MJA and a synthetic alpha-dimethylbutyryl thioester, albeit with suboptimal properties as a biocatalyst. | ||
Revision as of 00:17, 13 March 2011
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| 3hle, resolution 2.06Å () | |||||||||
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| Ligands: | , | ||||||||
| Related: | 1hld | ||||||||
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| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
==Introduction==
Simvastation synthase (LovD) is an enzyme isolatied from the natural product biosynthetic pathways ofAspergillus terreus. Simvastatin Synthase is an acyltransferase that converts the inactive monacolin J acid (MJA) into the cholesterol-lowering lovastatin.Image:LovD copy.jpg
LovD can also synthesize the blockbuster drug simvastatin using MJA and a synthetic alpha-dimethylbutyryl thioester, albeit with suboptimal properties as a biocatalyst.
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Michal Harel, Eric Ginter, David Canner, Alexander Berchansky
