2gvf
From Proteopedia
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[[Image:2gvf.png|left|200px]] | [[Image:2gvf.png|left|200px]] | ||
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{{STRUCTURE_2gvf| PDB=2gvf | SCENE= }} | {{STRUCTURE_2gvf| PDB=2gvf | SCENE= }} | ||
===HCV NS3-4A protease domain complexed with a macrocyclic ketoamide inhibitor, SCH419021=== | ===HCV NS3-4A protease domain complexed with a macrocyclic ketoamide inhibitor, SCH419021=== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:016730985</ref><ref group="xtra">PMID:008861917</ref><ref group="xtra">PMID:016352601</ref><ref group="xtra">PMID:016087332</ref><references group="xtra"/> |
[[Category: Hepatitis c virus]] | [[Category: Hepatitis c virus]] | ||
[[Category: Arasappan, A.]] | [[Category: Arasappan, A.]] | ||
Revision as of 12:15, 23 January 2013
HCV NS3-4A protease domain complexed with a macrocyclic ketoamide inhibitor, SCH419021
Template:ABSTRACT PUBMED 16730985
About this Structure
2gvf is a 4 chain structure with sequence from Hepatitis c virus. Full crystallographic information is available from OCA.
Reference
- Arasappan A, Njoroge FG, Chen KX, Venkatraman S, Parekh TN, Gu H, Pichardo J, Butkiewicz N, Prongay A, Madison V, Girijavallabhan V. P2-P4 macrocyclic inhibitors of hepatitis C virus NS3-4A serine protease. Bioorg Med Chem Lett. 2006 Aug 1;16(15):3960-5. Epub 2006 May 30. PMID:16730985 doi:10.1016/j.bmcl.2006.05.022
- Kim JL, Morgenstern KA, Lin C, Fox T, Dwyer MD, Landro JA, Chambers SP, Markland W, Lepre CA, O'Malley ET, Harbeson SL, Rice CM, Murcko MA, Caron PR, Thomson JA. Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide. Cell. 1996 Oct 18;87(2):343-55. PMID:8861917
- Yi M, Tong X, Skelton A, Chase R, Chen T, Prongay A, Bogen SL, Saksena AK, Njoroge FG, Veselenak RL, Pyles RB, Bourne N, Malcolm BA, Lemon SM. Mutations conferring resistance to SCH6, a novel hepatitis C virus NS3/4A protease inhibitor. Reduced RNA replication fitness and partial rescue by second-site mutations. J Biol Chem. 2006 Mar 24;281(12):8205-15. Epub 2005 Dec 13. PMID:16352601 doi:10.1074/jbc.M510246200
- Arasappan A, Njoroge FG, Chan TY, Bennett F, Bogen SL, Chen K, Gu H, Hong L, Jao E, Liu YT, Lovey RG, Parekh T, Pike RE, Pinto P, Santhanam B, Venkatraman S, Vaccaro H, Wang H, Yang X, Zhu Z, Mckittrick B, Saksena AK, Girijavallabhan V, Pichardo J, Butkiewicz N, Ingram R, Malcolm B, Prongay A, Yao N, Marten B, Madison V, Kemp S, Levy O, Lim-Wilby M, Tamura S, Ganguly AK. Hepatitis C virus NS3-4A serine protease inhibitors: SAR of P'2 moiety with improved potency. Bioorg Med Chem Lett. 2005 Oct 1;15(19):4180-4. PMID:16087332 doi:10.1016/j.bmcl.2005.06.091
