2i3h
From Proteopedia
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[[Image:2i3h.png|left|200px]] | [[Image:2i3h.png|left|200px]] | ||
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{{STRUCTURE_2i3h| PDB=2i3h | SCENE= }} | {{STRUCTURE_2i3h| PDB=2i3h | SCENE= }} | ||
===Structure of an ML-IAP/XIAP chimera bound to a 4-mer peptide (AVPW)=== | ===Structure of an ML-IAP/XIAP chimera bound to a 4-mer peptide (AVPW)=== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:017168540</ref><ref group="xtra">PMID:015485396</ref><ref group="xtra">PMID:012846571</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Fairbrother, W J.]] | [[Category: Fairbrother, W J.]] | ||
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[[Category: Apoptosis inhibition]] | [[Category: Apoptosis inhibition]] | ||
[[Category: Drug design]] | [[Category: Drug design]] | ||
| - | [[Category: Inhibitor | + | [[Category: Inhibitor-apoptosis complex]] |
[[Category: Peptide complex]] | [[Category: Peptide complex]] | ||
[[Category: Peptidomimetic]] | [[Category: Peptidomimetic]] | ||
[[Category: Small molecule]] | [[Category: Small molecule]] | ||
[[Category: Zinc binding]] | [[Category: Zinc binding]] | ||
Revision as of 13:01, 30 January 2013
Structure of an ML-IAP/XIAP chimera bound to a 4-mer peptide (AVPW)
Template:ABSTRACT PUBMED 17168540
About this Structure
2i3h is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Zobel K, Wang L, Varfolomeev E, Franklin MC, Elliott LO, Wallweber HJ, Okawa DC, Flygare JA, Vucic D, Fairbrother WJ, Deshayes K. Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs. ACS Chem Biol. 2006 Sep 19;1(8):525-33. PMID:17168540 doi:10.1021/cb600276q
- Vucic D, Franklin MC, Wallweber HJ, Das K, Eckelman BP, Shin H, Elliott LO, Kadkhodayan S, Deshayes K, Salvesen GS, Fairbrother WJ. Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP. Biochem J. 2005 Jan 1;385(Pt 1):11-20. PMID:15485396 doi:10.1042/BJ20041108
- Franklin MC, Kadkhodayan S, Ackerly H, Alexandru D, Distefano MD, Elliott LO, Flygare JA, Mausisa G, Okawa DC, Ong D, Vucic D, Deshayes K, Fairbrother WJ. Structure and function analysis of peptide antagonists of melanoma inhibitor of apoptosis (ML-IAP). Biochemistry. 2003 Jul 15;42(27):8223-31. PMID:12846571 doi:10.1021/bi034227t
