This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3hxq
From Proteopedia
m (Protected "3hxq" [edit=sysop:move=sysop]) |
|||
| Line 22: | Line 22: | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:018025536</ref><ref group="xtra">PMID:019422452</ref><ref group="xtra">PMID:019913482</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Diener, J L.]] | [[Category: Diener, J L.]] | ||
| Line 32: | Line 32: | ||
[[Category: Arc1772]] | [[Category: Arc1772]] | ||
[[Category: Arc1779]] | [[Category: Arc1779]] | ||
| - | [[Category: Blood clotting | + | [[Category: Blood clotting-blood clotting regulator complex]] |
[[Category: Blood coagulation]] | [[Category: Blood coagulation]] | ||
[[Category: Cell adhesion]] | [[Category: Cell adhesion]] | ||
| Line 43: | Line 43: | ||
[[Category: Isopeptide bond]] | [[Category: Isopeptide bond]] | ||
[[Category: Platelet glycoprotein ib]] | [[Category: Platelet glycoprotein ib]] | ||
| - | [[Category: Polymorphism]] | ||
[[Category: Secreted]] | [[Category: Secreted]] | ||
| - | [[Category: Ubl conjugation]] | ||
[[Category: Von willebrand disease]] | [[Category: Von willebrand disease]] | ||
[[Category: Vwf]] | [[Category: Vwf]] | ||
Revision as of 10:09, 16 November 2011
Crystal Structure of Von Willebrand Factor (VWF) A1 Domain in Complex with DNA Aptamer ARC1172, an Inhibitor of VWF-Platelet Binding
Template:ABSTRACT PUBMED 18025536
About this Structure
3hxq is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Gilbert JC, DeFeo-Fraulini T, Hutabarat RM, Horvath CJ, Merlino PG, Marsh HN, Healy JM, Boufakhreddine S, Holohan TV, Schaub RG. First-in-human evaluation of anti von Willebrand factor therapeutic aptamer ARC1779 in healthy volunteers. Circulation. 2007 Dec 4;116(23):2678-86. Epub 2007 Nov 19. PMID:18025536 doi:10.1161/CIRCULATIONAHA.107.724864
- Diener JL, Daniel Lagasse HA, Duerschmied D, Merhi Y, Tanguay JF, Hutabarat R, Gilbert J, Wagner DD, Schaub R. Inhibition of von Willebrand factor-mediated platelet activation and thrombosis by the anti-von Willebrand factor A1-domain aptamer ARC1779. J Thromb Haemost. 2009 Jul;7(7):1155-62. Epub 2009 Apr 24. PMID:19422452 doi:10.1111/j.1538-7836.2009.03459.x
- Huang RH, Fremont DH, Diener JL, Schaub RG, Sadler JE. A structural explanation for the antithrombotic activity of ARC1172, a DNA aptamer that binds von Willebrand factor domain A1. Structure. 2009 Nov 11;17(11):1476-84. PMID:19913482 doi:10.1016/j.str.2009.09.011
Categories: Homo sapiens | Diener, J L. | Fremont, D H. | Huang, R H. | Sadler, J E. | Schaub, R G. | Aptamer | Arc1772 | Arc1779 | Blood clotting-blood clotting regulator complex | Blood coagulation | Cell adhesion | Cleavage on pair of basic residue | Disease mutation | Disulfide bond | Extracellular matrix | Glycoprotein | Hemostasis | Isopeptide bond | Platelet glycoprotein ib | Secreted | Von willebrand disease | Vwf
