3d1x
From Proteopedia
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{{STRUCTURE_3d1x| PDB=3d1x | SCENE= }} | {{STRUCTURE_3d1x| PDB=3d1x | SCENE= }} | ||
===Crystal structure of HIV-1 mutant I54M and inhibitor saquinavir=== | ===Crystal structure of HIV-1 mutant I54M and inhibitor saquinavir=== | ||
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{{ABSTRACT_PUBMED_18597780}} | {{ABSTRACT_PUBMED_18597780}} | ||
==About this Structure== | ==About this Structure== | ||
| - | [[3d1x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D1X OCA]. | + | [[3d1x]] is a 2 chain structure of [[Virus protease]] with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D1X OCA]. |
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| + | ==See Also== | ||
| + | *[[Virus protease|Virus protease]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:018597780</ref><ref group="xtra">PMID:016962136</ref><ref group="xtra">PMID:016277992</ref><references group="xtra"/> |
[[Category: HIV-1 retropepsin]] | [[Category: HIV-1 retropepsin]] | ||
[[Category: Human immunodeficiency virus 1]] | [[Category: Human immunodeficiency virus 1]] | ||
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[[Category: Capsid maturation]] | [[Category: Capsid maturation]] | ||
[[Category: Capsid protein]] | [[Category: Capsid protein]] | ||
| - | [[Category: Cytoplasm]] | ||
| - | [[Category: Dna integration]] | ||
| - | [[Category: Dna recombination]] | ||
| - | [[Category: Dna-directed dna polymerase]] | ||
[[Category: Drug resistance]] | [[Category: Drug resistance]] | ||
| - | [[Category: Endonuclease]] | ||
[[Category: Flap mutant]] | [[Category: Flap mutant]] | ||
[[Category: Hiv-1]] | [[Category: Hiv-1]] | ||
| - | [[Category: Hydrolase]] | + | [[Category: Hydrolase-hydrolase inhibitor complex]] |
[[Category: I54m]] | [[Category: I54m]] | ||
| - | [[Category: Lipoprotein]] | ||
| - | [[Category: Magnesium]] | ||
| - | [[Category: Membrane]] | ||
| - | [[Category: Metal-binding]] | ||
| - | [[Category: Multifunctional enzyme]] | ||
| - | [[Category: Myristate]] | ||
| - | [[Category: Nuclease]] | ||
| - | [[Category: Nucleotidyltransferase]] | ||
| - | [[Category: Nucleus]] | ||
| - | [[Category: Phosphoprotein]] | ||
| - | [[Category: Protease]] | ||
| - | [[Category: Ribosomal frameshifting]] | ||
| - | [[Category: Rna-binding]] | ||
| - | [[Category: Rna-directed dna polymerase]] | ||
| - | [[Category: Transferase]] | ||
[[Category: Viral nucleoprotein]] | [[Category: Viral nucleoprotein]] | ||
| - | [[Category: Virion]] | ||
| - | [[Category: Zinc]] | ||
| - | [[Category: Zinc-finger]] | ||
Revision as of 03:17, 26 July 2012
Contents |
Crystal structure of HIV-1 mutant I54M and inhibitor saquinavir
Template:ABSTRACT PUBMED 18597780
About this Structure
3d1x is a 2 chain structure of Virus protease with sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.
See Also
Reference
- Liu F, Kovalevsky AY, Tie Y, Ghosh AK, Harrison RW, Weber IT. Effect of flap mutations on structure of HIV-1 protease and inhibition by saquinavir and darunavir. J Mol Biol. 2008 Aug 1;381(1):102-15. Epub 2008 Jul 1. PMID:18597780 doi:10.1016/j.jmb.2008.05.062
- Kovalevsky AY, Liu F, Leshchenko S, Ghosh AK, Louis JM, Harrison RW, Weber IT. Ultra-high resolution crystal structure of HIV-1 protease mutant reveals two binding sites for clinical inhibitor TMC114. J Mol Biol. 2006 Oct 13;363(1):161-73. Epub 2006 Aug 4. PMID:16962136 doi:10.1016/j.jmb.2006.08.007
- Liu F, Boross PI, Wang YF, Tozser J, Louis JM, Harrison RW, Weber IT. Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S. J Mol Biol. 2005 Dec 9;354(4):789-800. Epub 2005 Oct 21. PMID:16277992 doi:10.1016/j.jmb.2005.09.095
