3bdj
From Proteopedia
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[[Image:3bdj.png|left|200px]] | [[Image:3bdj.png|left|200px]] | ||
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{{STRUCTURE_3bdj| PDB=3bdj | SCENE= }} | {{STRUCTURE_3bdj| PDB=3bdj | SCENE= }} | ||
===Crystal Structure of Bovine Milk Xanthine Dehydrogenase with a Covalently Bound Oxipurinol Inhibitor=== | ===Crystal Structure of Bovine Milk Xanthine Dehydrogenase with a Covalently Bound Oxipurinol Inhibitor=== | ||
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{{ABSTRACT_PUBMED_18600558}} | {{ABSTRACT_PUBMED_18600558}} | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:018600558</ref><ref group="xtra">PMID:011796116</ref><ref group="xtra">PMID:015148401</ref><ref group="xtra">PMID:015190124</ref><ref group="xtra">PMID:012421831</ref><references group="xtra"/> |
[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
[[Category: Eger, B T.]] | [[Category: Eger, B T.]] | ||
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[[Category: Okamoto, K.]] | [[Category: Okamoto, K.]] | ||
[[Category: Pai, E F.]] | [[Category: Pai, E F.]] | ||
| - | [[Category: 2fe-2]] | ||
[[Category: Allopurinol]] | [[Category: Allopurinol]] | ||
[[Category: Alloxanthine]] | [[Category: Alloxanthine]] | ||
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[[Category: Iron-sulfur]] | [[Category: Iron-sulfur]] | ||
[[Category: Molybdopterin]] | [[Category: Molybdopterin]] | ||
| + | [[Category: Oxidoreductase]] | ||
[[Category: Oxipurinol]] | [[Category: Oxipurinol]] | ||
[[Category: Oxypurinol]] | [[Category: Oxypurinol]] | ||
Revision as of 13:43, 6 February 2013
Crystal Structure of Bovine Milk Xanthine Dehydrogenase with a Covalently Bound Oxipurinol Inhibitor
Template:ABSTRACT PUBMED 18600558
About this Structure
3bdj is a 2 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA.
Reference
- Okamoto K, Eger BT, Nishino T, Pai EF, Nishino T. Mechanism of inhibition of xanthine oxidoreductase by allopurinol: crystal structure of reduced bovine milk xanthine oxidoreductase bound with oxipurinol. Nucleosides Nucleotides Nucleic Acids. 2008 Jun;27(6):888-93. PMID:18600558 doi:794699692
- Truglio JJ, Theis K, Leimkuhler S, Rappa R, Rajagopalan KV, Kisker C. Crystal structures of the active and alloxanthine-inhibited forms of xanthine dehydrogenase from Rhodobacter capsulatus. Structure. 2002 Jan;10(1):115-25. PMID:11796116
- Okamoto K, Matsumoto K, Hille R, Eger BT, Pai EF, Nishino T. The crystal structure of xanthine oxidoreductase during catalysis: implications for reaction mechanism and enzyme inhibition. Proc Natl Acad Sci U S A. 2004 May 25;101(21):7931-6. Epub 2004 May 17. PMID:15148401 doi:10.1073/pnas.0400973101
- Fukunari A, Okamoto K, Nishino T, Eger BT, Pai EF, Kamezawa M, Yamada I, Kato N. Y-700 [1-[3-Cyano-4-(2,2-dimethylpropoxy)phenyl]-1H-pyrazole-4-carboxylic acid]: a potent xanthine oxidoreductase inhibitor with hepatic excretion. J Pharmacol Exp Ther. 2004 Nov;311(2):519-28. Epub 2004 Jun 9. PMID:15190124 doi:10.1124/jpet.104.070433
- Okamoto K, Eger BT, Nishino T, Kondo S, Pai EF, Nishino T. An extremely potent inhibitor of xanthine oxidoreductase. Crystal structure of the enzyme-inhibitor complex and mechanism of inhibition. J Biol Chem. 2003 Jan 17;278(3):1848-55. Epub 2002 Nov 5. PMID:12421831 doi:10.1074/jbc.M208307200
Categories: Bos taurus | Eger, B T. | Nishino, T. | Okamoto, K. | Pai, E F. | Allopurinol | Alloxanthine | Covalently bound inhibitor | Fad | Flavoprotein | Iron-sulfur | Molybdopterin | Oxidoreductase | Oxipurinol | Oxypurinol | Peroxisome | Xanthine dehydrogenase | Xanthine oxidase | Xanthine oxidoreductase
