1zvx

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[[Image:1zvx.png|left|200px]]
[[Image:1zvx.png|left|200px]]
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{{STRUCTURE_1zvx| PDB=1zvx | SCENE= }}
{{STRUCTURE_1zvx| PDB=1zvx | SCENE= }}
===Crystal structure of the complex between MMP-8 and a phosphonate inhibitor (R-enantiomer)===
===Crystal structure of the complex between MMP-8 and a phosphonate inhibitor (R-enantiomer)===
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{{ABSTRACT_PUBMED_16451058}}
{{ABSTRACT_PUBMED_16451058}}
==About this Structure==
==About this Structure==
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[[1zvx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZVX OCA].
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[[1zvx]] is a 1 chain structure of [[Matrix metalloproteinase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZVX OCA].
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==See Also==
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*[[Matrix metalloproteinase|Matrix metalloproteinase]]
==Reference==
==Reference==
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<ref group="xtra">PMID:16451058</ref><ref group="xtra">PMID:10422833</ref><ref group="xtra">PMID:10978185</ref><ref group="xtra">PMID:7737183</ref><references group="xtra"/>
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<ref group="xtra">PMID:016451058</ref><ref group="xtra">PMID:010422833</ref><ref group="xtra">PMID:010978185</ref><ref group="xtra">PMID:007737183</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Neutrophil collagenase]]
[[Category: Neutrophil collagenase]]

Revision as of 07:47, 27 July 2012

Image:1zvx.png

Template:STRUCTURE 1zvx

Contents

Crystal structure of the complex between MMP-8 and a phosphonate inhibitor (R-enantiomer)

Template:ABSTRACT PUBMED 16451058

About this Structure

1zvx is a 1 chain structure of Matrix metalloproteinase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Pochetti G, Gavuzzo E, Campestre C, Agamennone M, Tortorella P, Consalvi V, Gallina C, Hiller O, Tschesche H, Tucker PA, Mazza F. Structural insight into the stereoselective inhibition of MMP-8 by enantiomeric sulfonamide phosphonates. J Med Chem. 2006 Feb 9;49(3):923-31. PMID:16451058 doi:10.1021/jm050787+
  • Pavlovsky AG, Williams MG, Ye QZ, Ortwine DF, Purchase CF 2nd, White AD, Dhanaraj V, Roth BD, Johnson LL, Hupe D, Humblet C, Blundell TL. X-ray structure of human stromelysin catalytic domain complexed with nonpeptide inhibitors: implications for inhibitor selectivity. Protein Sci. 1999 Jul;8(7):1455-62. PMID:10422833
  • Gavuzzo E, Pochetti G, Mazza F, Gallina C, Gorini B, D'Alessio S, Pieper M, Tschesche H, Tucker PA. Two crystal structures of human neutrophil collagenase, one complexed with a primed- and the other with an unprimed-side inhibitor: implications for drug design. J Med Chem. 2000 Sep 7;43(18):3377-85. PMID:10978185
  • Grams F, Reinemer P, Powers JC, Kleine T, Pieper M, Tschesche H, Huber R, Bode W. X-ray structures of human neutrophil collagenase complexed with peptide hydroxamate and peptide thiol inhibitors. Implications for substrate binding and rational drug design. Eur J Biochem. 1995 Mar 15;228(3):830-41. PMID:7737183

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