3hkj

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[[Image:3hkj.png|left|200px]]
[[Image:3hkj.png|left|200px]]
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{{STRUCTURE_3hkj| PDB=3hkj | SCENE= }}
{{STRUCTURE_3hkj| PDB=3hkj | SCENE= }}
===Crystal structure of human thrombin mutant W215A/E217A in complex with the extracellular fragment of human PAR1===
===Crystal structure of human thrombin mutant W215A/E217A in complex with the extracellular fragment of human PAR1===
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{{ABSTRACT_PUBMED_19586901}}
{{ABSTRACT_PUBMED_19586901}}
==About this Structure==
==About this Structure==
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[[3hkj]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HKJ OCA].
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[[3hkj]] is a 6 chain structure of [[Thrombin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HKJ OCA].
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==See Also==
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*[[Thrombin|Thrombin]]
==Reference==
==Reference==
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<ref group="xtra">PMID:19586901</ref><ref group="xtra">PMID:15252033</ref><references group="xtra"/>
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<ref group="xtra">PMID:019586901</ref><ref group="xtra">PMID:015252033</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Thrombin]]
[[Category: Thrombin]]
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[[Category: Acute phase]]
[[Category: Acute phase]]
[[Category: Blood coagulation]]
[[Category: Blood coagulation]]
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[[Category: Calcium]]
 
[[Category: Cell membrane]]
[[Category: Cell membrane]]
[[Category: Cleavage on pair of basic residue]]
[[Category: Cleavage on pair of basic residue]]
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[[Category: Kringle]]
[[Category: Kringle]]
[[Category: Membrane]]
[[Category: Membrane]]
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[[Category: Pharmaceutical]]
 
[[Category: Phosphoprotein]]
[[Category: Phosphoprotein]]
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[[Category: Polymorphism]]
 
[[Category: Protease]]
[[Category: Protease]]
[[Category: Receptor]]
[[Category: Receptor]]

Revision as of 11:13, 27 July 2012

Image:3hkj.png

Template:STRUCTURE 3hkj

Contents

Crystal structure of human thrombin mutant W215A/E217A in complex with the extracellular fragment of human PAR1

Template:ABSTRACT PUBMED 19586901

About this Structure

3hkj is a 6 chain structure of Thrombin with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Gandhi PS, Page MJ, Chen Z, Bush-Pelc L, Di Cera E. Mechanism of the anticoagulant activity of thrombin mutant W215A/E217A. J Biol Chem. 2009 Sep 4;284(36):24098-105. Epub 2009 Jul 8. PMID:19586901 doi:10.1074/jbc.M109.025403
  • Pineda AO, Chen ZW, Caccia S, Cantwell AM, Savvides SN, Waksman G, Mathews FS, Di Cera E. The anticoagulant thrombin mutant W215A/E217A has a collapsed primary specificity pocket. J Biol Chem. 2004 Sep 17;279(38):39824-8. Epub 2004 Jul 13. PMID:15252033 doi:http://dx.doi.org/10.1074/jbc.M407272200

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