This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2vuk
From Proteopedia
m (Protected "2vuk" [edit=sysop:move=sysop]) |
Revision as of 21:00, 14 March 2011
STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO THE STABILIZING SMALL-MOLECULE DRUG PHIKAN083
Template:ABSTRACT PUBMED 18650397
About this Structure
2vuk is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Boeckler FM, Joerger AC, Jaggi G, Rutherford TJ, Veprintsev DB, Fersht AR. Targeted rescue of a destabilized mutant of p53 by an in silico screened drug. Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10360-5. Epub 2008 Jul 23. PMID:18650397
- Joerger AC, Ang HC, Fersht AR. Structural basis for understanding oncogenic p53 mutations and designing rescue drugs. Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15056-61. Epub 2006 Oct 2. PMID:17015838
Categories: Homo sapiens | Boeckler, F M. | Fersht, A R. | Joerger, A C. | Acetylation | Activator | Alternative splicing | Anti-oncogene | Apoptosis | Cancer | Cell cycle | Covalent protein-rna linkage | Cytoplasm | Disease mutation | Dna binding | Dna-binding | Dna-binding protein | Endoplasmic reticulum | Glycoprotein | Host-virus interaction | Li-fraumeni syndrome | Metal binding | Metal-binding | Methylation | Nuclear protein | Nucleus | P53 dna- binding domain | Phosphoprotein | Polymorphism | Protein stabilization | Second-site suppressor mutation | Small-molecule drug | Superstable mutant | Surface crevice | Transcription | Transcription regulation | Tumor suppressor | Ubl conjugation | Virtual screening | Zinc
