1uol

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[[Image:1uol.png|left|200px]]
[[Image:1uol.png|left|200px]]
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{{STRUCTURE_1uol| PDB=1uol | SCENE= }}
{{STRUCTURE_1uol| PDB=1uol | SCENE= }}
===CRYSTAL STRUCTURE OF THE HUMAN P53 CORE DOMAIN MUTANT M133L/V203A/N239Y/N268D AT 1.9 A RESOLUTION.===
===CRYSTAL STRUCTURE OF THE HUMAN P53 CORE DOMAIN MUTANT M133L/V203A/N239Y/N268D AT 1.9 A RESOLUTION.===
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{{ABSTRACT_PUBMED_14534297}}
{{ABSTRACT_PUBMED_14534297}}
==About this Structure==
==About this Structure==
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[[1uol]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UOL OCA].
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[[1uol]] is a 2 chain structure of [[P53]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UOL OCA].
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==See Also==
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*[[P53|P53]]
==Reference==
==Reference==
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<ref group="xtra">PMID:14534297</ref><ref group="xtra">PMID:9843948</ref><ref group="xtra">PMID:8023157</ref><references group="xtra"/>
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<ref group="xtra">PMID:014534297</ref><ref group="xtra">PMID:009843948</ref><ref group="xtra">PMID:008023157</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Allen, M D.]]
[[Category: Allen, M D.]]

Revision as of 18:13, 25 July 2012

Image:1uol.png

Template:STRUCTURE 1uol

Contents

CRYSTAL STRUCTURE OF THE HUMAN P53 CORE DOMAIN MUTANT M133L/V203A/N239Y/N268D AT 1.9 A RESOLUTION.

Template:ABSTRACT PUBMED 14534297

About this Structure

1uol is a 2 chain structure of P53 with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Joerger AC, Allen MD, Fersht AR. Crystal structure of a superstable mutant of human p53 core domain. Insights into the mechanism of rescuing oncogenic mutations. J Biol Chem. 2004 Jan 9;279(2):1291-6. Epub 2003 Oct 8. PMID:14534297 doi:10.1074/jbc.M309732200
  • Nikolova PV, Henckel J, Lane DP, Fersht AR. Semirational design of active tumor suppressor p53 DNA binding domain with enhanced stability. Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):14675-80. PMID:9843948
  • Cho Y, Gorina S, Jeffrey PD, Pavletich NP. Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations. Science. 1994 Jul 15;265(5170):346-55. PMID:8023157

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