2pgb

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Revision as of 21:49, 14 March 2011

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Template:STRUCTURE 2pgb

Inhibitor-free human thrombin mutant C191A-C220A

Template:ABSTRACT PUBMED 17636263

About this Structure

2pgb is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

• Bush-Pelc LA, Marino F, Chen Z, Pineda AO, Mathews FS, Di Cera E. Important role of the cys-191 cys-220 disulfide bond in thrombin function and allostery. J Biol Chem. 2007 Sep 14;282(37):27165-70. Epub 2007 Jul 18. PMID:17636263 doi:10.1074/jbc.M703202200
• Pineda AO, Carrell CJ, Bush LA, Prasad S, Caccia S, Chen ZW, Mathews FS, Di Cera E. Molecular dissection of Na+ binding to thrombin. J Biol Chem. 2004 Jul 23;279(30):31842-53. Epub 2004 May 19. PMID:15152000 doi:http://dx.doi.org/10.1074/jbc.M401756200