2j4g

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Revision as of 22:06, 14 March 2011

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Template:STRUCTURE 2j4g

BACTEROIDES THETAIOTAOMICRON GH84 O-GLCNACASE IN COMPLEX WITH N-BUTYL-THIAZOLINE INHIBITOR

Template:ABSTRACT PUBMED 17227027

About this Structure

2j4g is a 2 chain structure with sequence from Bacteroides thetaiotaomicron. Full crystallographic information is available from OCA.

Reference

• Whitworth GE, Macauley MS, Stubbs KA, Dennis RJ, Taylor EJ, Davies GJ, Greig IR, Vocadlo DJ. Analysis of PUGNAc and NAG-thiazoline as transition state analogues for human O-GlcNAcase: mechanistic and structural insights into inhibitor selectivity and transition state poise. J Am Chem Soc. 2007 Jan 24;129(3):635-44. PMID:17227027 doi:http://dx.doi.org/10.1021/ja065697o
• Dennis RJ, Taylor EJ, Macauley MS, Stubbs KA, Turkenburg JP, Hart SJ, Black GN, Vocadlo DJ, Davies GJ. Structure and mechanism of a bacterial beta-glucosaminidase having O-GlcNAcase activity. Nat Struct Mol Biol. 2006 Apr;13(4):365-71. Epub 2006 Mar 26. PMID:16565725 doi:http://dx.doi.org/10.1038/nsmb1079