This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3d20
From Proteopedia
m (Protected "3d20" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
[[Image:3d20.png|left|200px]] | [[Image:3d20.png|left|200px]] | ||
| - | <!-- | ||
| - | The line below this paragraph, containing "STRUCTURE_3d20", creates the "Structure Box" on the page. | ||
| - | You may change the PDB parameter (which sets the PDB file loaded into the applet) | ||
| - | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | ||
| - | or leave the SCENE parameter empty for the default display. | ||
| - | --> | ||
{{STRUCTURE_3d20| PDB=3d20 | SCENE= }} | {{STRUCTURE_3d20| PDB=3d20 | SCENE= }} | ||
===Crystal structure of HIV-1 mutant I54V and inhibitor DARUNAVIA=== | ===Crystal structure of HIV-1 mutant I54V and inhibitor DARUNAVIA=== | ||
| - | |||
| - | <!-- | ||
| - | The line below this paragraph, {{ABSTRACT_PUBMED_18597780}}, adds the Publication Abstract to the page | ||
| - | (as it appears on PubMed at http://www.pubmed.gov), where 18597780 is the PubMed ID number. | ||
| - | --> | ||
{{ABSTRACT_PUBMED_18597780}} | {{ABSTRACT_PUBMED_18597780}} | ||
==About this Structure== | ==About this Structure== | ||
| - | [[3d20]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D20 OCA]. | + | [[3d20]] is a 2 chain structure of [[Virus protease]] with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D20 OCA]. |
| + | |||
| + | ==See Also== | ||
| + | *[[Virus protease|Virus protease]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:018597780</ref><ref group="xtra">PMID:016962136</ref><ref group="xtra">PMID:016277992</ref><references group="xtra"/> |
[[Category: HIV-1 retropepsin]] | [[Category: HIV-1 retropepsin]] | ||
[[Category: Human immunodeficiency virus 1]] | [[Category: Human immunodeficiency virus 1]] | ||
| Line 35: | Line 27: | ||
[[Category: Capsid maturation]] | [[Category: Capsid maturation]] | ||
[[Category: Capsid protein]] | [[Category: Capsid protein]] | ||
| - | [[Category: Cytoplasm]] | ||
[[Category: Dna integration]] | [[Category: Dna integration]] | ||
[[Category: Dna recombination]] | [[Category: Dna recombination]] | ||
| Line 56: | Line 47: | ||
[[Category: Phosphoprotein]] | [[Category: Phosphoprotein]] | ||
[[Category: Protease]] | [[Category: Protease]] | ||
| - | [[Category: Ribosomal frameshifting]] | ||
[[Category: Rna-binding]] | [[Category: Rna-binding]] | ||
[[Category: Rna-directed dna polymerase]] | [[Category: Rna-directed dna polymerase]] | ||
| Line 62: | Line 52: | ||
[[Category: Viral nucleoprotein]] | [[Category: Viral nucleoprotein]] | ||
[[Category: Virion]] | [[Category: Virion]] | ||
| - | [[Category: Zinc]] | ||
[[Category: Zinc-finger]] | [[Category: Zinc-finger]] | ||
Revision as of 01:57, 27 July 2012
Contents |
Crystal structure of HIV-1 mutant I54V and inhibitor DARUNAVIA
Template:ABSTRACT PUBMED 18597780
About this Structure
3d20 is a 2 chain structure of Virus protease with sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.
See Also
Reference
- Liu F, Kovalevsky AY, Tie Y, Ghosh AK, Harrison RW, Weber IT. Effect of flap mutations on structure of HIV-1 protease and inhibition by saquinavir and darunavir. J Mol Biol. 2008 Aug 1;381(1):102-15. Epub 2008 Jul 1. PMID:18597780 doi:10.1016/j.jmb.2008.05.062
- Kovalevsky AY, Liu F, Leshchenko S, Ghosh AK, Louis JM, Harrison RW, Weber IT. Ultra-high resolution crystal structure of HIV-1 protease mutant reveals two binding sites for clinical inhibitor TMC114. J Mol Biol. 2006 Oct 13;363(1):161-73. Epub 2006 Aug 4. PMID:16962136 doi:10.1016/j.jmb.2006.08.007
- Liu F, Boross PI, Wang YF, Tozser J, Louis JM, Harrison RW, Weber IT. Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S. J Mol Biol. 2005 Dec 9;354(4):789-800. Epub 2005 Oct 21. PMID:16277992 doi:10.1016/j.jmb.2005.09.095
Categories: HIV-1 retropepsin | Human immunodeficiency virus 1 | Ghosh, A K. | Harrison, R W. | Kovalesky, A Y. | Liu, F. | Tie, Y. | Weber, I T. | Aid | Aspartyl protease | Capsid maturation | Capsid protein | Dna integration | Dna recombination | Dna-directed dna polymerase | Drug resistance | Endonuclease | Flap mutant | Hiv-1 | Hydrolase | I54v | Lipoprotein | Magnesium | Membrane | Metal-binding | Multifunctional enzyme | Myristate | Nuclease | Nucleotidyltransferase | Nucleus | Phosphoprotein | Protease | Rna-binding | Rna-directed dna polymerase | Transferase | Viral nucleoprotein | Virion | Zinc-finger
