2x0v

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{{STRUCTURE_2x0v| PDB=2x0v | SCENE= }}
{{STRUCTURE_2x0v| PDB=2x0v | SCENE= }}
===STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO 4-(TRIFLUOROMETHYL)BENZENE-1,2-DIAMINE===
===STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO 4-(TRIFLUOROMETHYL)BENZENE-1,2-DIAMINE===
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{{ABSTRACT_PUBMED_20142040}}
{{ABSTRACT_PUBMED_20142040}}
==About this Structure==
==About this Structure==
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[[2x0v]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X0V OCA].
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[[2x0v]] is a 2 chain structure of [[P53]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X0V OCA].
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==See Also==
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*[[P53|P53]]
==Reference==
==Reference==
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<ref group="xtra">PMID:20142040</ref><ref group="xtra">PMID:17015838</ref><references group="xtra"/>
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<ref group="xtra">PMID:020142040</ref><ref group="xtra">PMID:017015838</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Basse, N.]]
[[Category: Basse, N.]]

Revision as of 18:29, 25 July 2012

Image:2x0v.png

Template:STRUCTURE 2x0v

Contents

STRUCTURE OF THE P53 CORE DOMAIN MUTANT Y220C BOUND TO 4-(TRIFLUOROMETHYL)BENZENE-1,2-DIAMINE

Template:ABSTRACT PUBMED 20142040

About this Structure

2x0v is a 2 chain structure of P53 with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Basse N, Kaar JL, Settanni G, Joerger AC, Rutherford TJ, Fersht AR. Toward the rational design of p53-stabilizing drugs: probing the surface of the oncogenic Y220C mutant. Chem Biol. 2010 Jan 29;17(1):46-56. PMID:20142040 doi:10.1016/j.chembiol.2009.12.011
  • Joerger AC, Ang HC, Fersht AR. Structural basis for understanding oncogenic p53 mutations and designing rescue drugs. Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15056-61. Epub 2006 Oct 2. PMID:17015838

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