3puk
From Proteopedia
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{{STRUCTURE_3puk| PDB=3puk | SCENE= }} | {{STRUCTURE_3puk| PDB=3puk | SCENE= }} | ||
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===Re-refinement of the crystal structure of Munc18-3 and Syntaxin4 N-peptide complex=== | ===Re-refinement of the crystal structure of Munc18-3 and Syntaxin4 N-peptide complex=== | ||
| + | {{ABSTRACT_PUBMED_21193638}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/STXB3_MOUSE STXB3_MOUSE]] Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes.<ref>PMID:9045631</ref> [[http://www.uniprot.org/uniprot/STX4_MOUSE STX4_MOUSE]] Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes and in docking of synaptic vesicles at presynaptic active zones.<ref>PMID:9045631</ref> <ref>PMID:10394363</ref> <ref>PMID:18827011</ref> | |
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==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:021193638</ref><ref group="xtra">PMID:017517664</ref><references group="xtra"/><references/> |
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Christie, M P.]] | [[Category: Christie, M P.]] | ||
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[[Category: Martin, J L.]] | [[Category: Martin, J L.]] | ||
[[Category: Saez, N J.]] | [[Category: Saez, N J.]] | ||
| + | [[Category: Endocytosis-exocytosis complex]] | ||
| + | [[Category: Membrane trafficking]] | ||
| + | [[Category: Sm protein]] | ||
| + | [[Category: Snare protein]] | ||
| + | [[Category: Syntaxin]] | ||
| + | [[Category: Syntaxin binding protein]] | ||
Revision as of 08:09, 8 May 2013
Contents |
Re-refinement of the crystal structure of Munc18-3 and Syntaxin4 N-peptide complex
Template:ABSTRACT PUBMED 21193638
Function
[STXB3_MOUSE] Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes.[1] [STX4_MOUSE] Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes and in docking of synaptic vesicles at presynaptic active zones.[2] [3] [4]
About this Structure
3puk is a 4 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
- Hu SH, Christie MP, Saez NJ, Latham CF, Jarrott R, Lua LH, Collins BM, Martin JL. Possible roles for Munc18-1 domain 3a and Syntaxin1 N-peptide and C-terminal anchor in SNARE complex formation. Proc Natl Acad Sci U S A. 2010 Dec 30. PMID:21193638 doi:10.1073/pnas.0914906108
- Hu SH, Latham CF, Gee CL, James DE, Martin JL. Structure of the Munc18c/Syntaxin4 N-peptide complex defines universal features of the N-peptide binding mode of Sec1/Munc18 proteins. Proc Natl Acad Sci U S A. 2007 May 22;104(21):8773-8. Epub 2007 May 16. PMID:17517664
- ↑ Tellam JT, Macaulay SL, McIntosh S, Hewish DR, Ward CW, James DE. Characterization of Munc-18c and syntaxin-4 in 3T3-L1 adipocytes. Putative role in insulin-dependent movement of GLUT-4. J Biol Chem. 1997 Mar 7;272(10):6179-86. PMID:9045631
- ↑ Tellam JT, Macaulay SL, McIntosh S, Hewish DR, Ward CW, James DE. Characterization of Munc-18c and syntaxin-4 in 3T3-L1 adipocytes. Putative role in insulin-dependent movement of GLUT-4. J Biol Chem. 1997 Mar 7;272(10):6179-86. PMID:9045631
- ↑ Min J, Okada S, Kanzaki M, Elmendorf JS, Coker KJ, Ceresa BP, Syu LJ, Noda Y, Saltiel AR, Pessin JE. Synip: a novel insulin-regulated syntaxin 4-binding protein mediating GLUT4 translocation in adipocytes. Mol Cell. 1999 Jun;3(6):751-60. PMID:10394363
- ↑ Pooley RD, Moynihan KL, Soukoulis V, Reddy S, Francis R, Lo C, Ma LJ, Bader DM. Murine CENPF interacts with syntaxin 4 in the regulation of vesicular transport. J Cell Sci. 2008 Oct 15;121(Pt 20):3413-21. doi: 10.1242/jcs.032847. Epub 2008, Sep 30. PMID:18827011 doi:10.1242/jcs.032847
