3ky9

From Proteopedia

Revision as of 22:19, 14 March 2011 (edit) OCA (Talk | contribs) ← Previous diff

Revision as of 22:20, 14 March 2011 (edit) (undo) OCA (Talk | contribs) m (Protected "3ky9" [edit=sysop:move=sysop]) Next diff →

---

Revision as of 22:20, 14 March 2011

proteopedia linkproteopedia link

Template:STRUCTURE 3ky9

Autoinhibited Vav1

Template:ABSTRACT PUBMED 20141838

About this Structure

3ky9 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

• Yu B, Martins IR, Li P, Amarasinghe GK, Umetani J, Fernandez-Zapico ME, Billadeau DD, Machius M, Tomchick DR, Rosen MK. Structural and energetic mechanisms of cooperative autoinhibition and activation of Vav1. Cell. 2010 Jan 22;140(2):246-56. PMID:20141838 doi:10.1016/j.cell.2009.12.033
• Li P, Martins IR, Amarasinghe GK, Rosen MK. Internal dynamics control activation and activity of the autoinhibited Vav DH domain. Nat Struct Mol Biol. 2008 Jun;15(6):613-8. Epub 2008 May 18. PMID:18488041 doi:10.1038/nsmb.1428
• Amarasinghe GK, Rosen MK. Acidic region tyrosines provide access points for allosteric activation of the autoinhibited Vav1 Dbl homology domain. Biochemistry. 2005 Nov 22;44(46):15257-68. PMID:16285729 doi:10.1021/bi051126h
• Aghazadeh B, Lowry WE, Huang XY, Rosen MK. Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation. Cell. 2000 Sep 1;102(5):625-33. PMID:11007481