2j5y
From Proteopedia
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==Overview== | ==Overview== | ||
| - | The albumin-binding domain, or GA module, of the peptostreptococcal | + | The albumin-binding domain, or GA module, of the peptostreptococcal albumin-binding protein expressed in pathogenic strains of Finegoldia magna is believed to be responsible for the virulence and increased growth rate of these strains. Here we present the 1.4A crystal structure of this domain, and compare it with the crystal structure of the GA-albumin complex. An analysis of protein-protein interactions in the two crystals, and the presence of multimeric GA species in solution, indicate the GA module is "sticky", and is capable of forming contacts with a range of protein surfaces. This might lead to interactions with different host proteins. |
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | Crystal structure of a bacterial albumin-binding domain at 1. | + | Crystal structure of a bacterial albumin-binding domain at 1.4 A resolution., Cramer JF, Nordberg PA, Hajdu J, Lejon S, FEBS Lett. 2007 Jul 10;581(17):3178-82. Epub 2007 Jun 12. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17575979 17575979] |
[[Category: Finegoldia magna]] | [[Category: Finegoldia magna]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Cramer, J | + | [[Category: Cramer, J F.]] |
[[Category: Lejon, S.]] | [[Category: Lejon, S.]] | ||
[[Category: Lundqvist, T.]] | [[Category: Lundqvist, T.]] | ||
| - | [[Category: Nordberg, P | + | [[Category: Nordberg, P A.]] |
[[Category: Valegard, K.]] | [[Category: Valegard, K.]] | ||
[[Category: cell wall]] | [[Category: cell wall]] | ||
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[[Category: protein binding bacterial albumin-binding three-helix bundle]] | [[Category: protein binding bacterial albumin-binding three-helix bundle]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:59:33 2008'' |
Revision as of 15:59, 21 February 2008
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CRYSTAL STRUCTURE OF THE GA MODULE FROM F.MAGNA
Overview
The albumin-binding domain, or GA module, of the peptostreptococcal albumin-binding protein expressed in pathogenic strains of Finegoldia magna is believed to be responsible for the virulence and increased growth rate of these strains. Here we present the 1.4A crystal structure of this domain, and compare it with the crystal structure of the GA-albumin complex. An analysis of protein-protein interactions in the two crystals, and the presence of multimeric GA species in solution, indicate the GA module is "sticky", and is capable of forming contacts with a range of protein surfaces. This might lead to interactions with different host proteins.
About this Structure
2J5Y is a Single protein structure of sequence from Finegoldia magna. Full crystallographic information is available from OCA.
Reference
Crystal structure of a bacterial albumin-binding domain at 1.4 A resolution., Cramer JF, Nordberg PA, Hajdu J, Lejon S, FEBS Lett. 2007 Jul 10;581(17):3178-82. Epub 2007 Jun 12. PMID:17575979
Page seeded by OCA on Thu Feb 21 17:59:33 2008
