2k4l

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Revision as of 22:38, 14 March 2011

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Template:STRUCTURE 2k4l

Solution structure of a 2:1C2-(2-naphthyl)pyrrolo[2,1-c][1,4]benzodiazepine (PBD) DNA adduct: molecular basis for unexpectedly high DNA helix stabilization.

Template:ABSTRACT PUBMED 18925745

About this Structure

2k4l is a 2 chain structure. Full experimental information is available from OCA.

Reference

• Antonow D, Barata T, Jenkins TC, Parkinson GN, Howard PW, Thurston DE, Zloh M. Solution Structure of a 2:1 C2-(2-Naphthyl) Pyrrolo[2,1-c][1,4]benzodiazepine DNA Adduct: Molecular Basis for Unexpectedly High DNA Helix Stabilization. Biochemistry. 2008 Oct 17. PMID:18925745 doi:10.1021/bi801225q
• Antonow D, Cooper N, Howard PW, Thurston DE. Parallel synthesis of a novel C2-aryl pyrrolo[2,1-c][1,4]benzodiazepine (PBD) library. J Comb Chem. 2007 May-Jun;9(3):437-45. Epub 2007 Mar 31. PMID:17397227 doi:10.1021/cc0601332