1a4x

From Proteopedia

Revision as of 12:40, 30 October 2007

PYRR, THE BACILLUS SUBTILIS PYRIMIDINE BIOSYNTHETIC OPERON REPRESSOR, HEXAMERIC FORM

Overview

BACKGROUND: The expression of pyrimidine nucleotide biosynthetic (pyr), genes in Bacillus subtilis is regulated by transcriptional attenuation., The PyrR attenuation protein binds to specific sites in pyr mRNA, allowing, the formation of downstream terminator structures. UMP and, 5-phosphoribosyl-1-pyrophosphate (PRPP), a nucleotide metabolite, are, co-regulators with PyrR. The smallest RNA shown to bind tightly to PyrR is, a 28-30 nucleotide stem-loop that contains a purine-rich bulge and a, putative-GNRA tetraloop. PyrR is also a uracil phosphoribosyltransferase, (UPRTase), although the relationship between enzymatic activity and RNA, recognition is unclear, and the UPRTase activity of PyrR is not, physiologically significant in B. subtilis. Elucidating the role of PyrR, structural ... [(full description)]

About this Structure

1A4X is a [Single protein] structure of sequence from [Bacillus subtilis] with SO4 as [ligand]. Structure known Active Sites: PRA and PRB. Full crystallographic information is available from [OCA].

Reference

Adaptation of an enzyme to regulatory function: structure of Bacillus subtilis PyrR, a pyr RNA-binding attenuation protein and uracil phosphoribosyltransferase., Tomchick DR, Turner RJ, Switzer RL, Smith JL, Structure. 1998 Mar 15;6(3):337-50. PMID:9551555

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