3gt9
From Proteopedia
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[[Image:3gt9.png|left|200px]] | [[Image:3gt9.png|left|200px]] | ||
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{{STRUCTURE_3gt9| PDB=3gt9 | SCENE= }} | {{STRUCTURE_3gt9| PDB=3gt9 | SCENE= }} | ||
===Structure of an ML-IAP/XIAP chimera bound to a peptidomimetic=== | ===Structure of an ML-IAP/XIAP chimera bound to a peptidomimetic=== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:020189383</ref><ref group="xtra">PMID:017168540</ref><ref group="xtra">PMID:015485396</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Cohen, F.]] | [[Category: Cohen, F.]] | ||
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[[Category: Apoptosis]] | [[Category: Apoptosis]] | ||
[[Category: Apoptosis inhibition]] | [[Category: Apoptosis inhibition]] | ||
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[[Category: Drug design]] | [[Category: Drug design]] | ||
[[Category: Metal-binding]] | [[Category: Metal-binding]] | ||
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[[Category: Peptidomimetic]] | [[Category: Peptidomimetic]] | ||
[[Category: Small molecule]] | [[Category: Small molecule]] | ||
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[[Category: Zinc binding]] | [[Category: Zinc binding]] | ||
Revision as of 15:46, 27 February 2013
Structure of an ML-IAP/XIAP chimera bound to a peptidomimetic
Template:ABSTRACT PUBMED 20189383
About this Structure
3gt9 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Cohen F, Koehler MF, Bergeron P, Elliott LO, Flygare JA, Franklin MC, Gazzard L, Keteltas SF, Lau K, Ly CQ, Tsui V, Fairbrother WJ. Antagonists of inhibitor of apoptosis proteins based on thiazole amide isosteres. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2229-33. Epub 2010 Feb 8. PMID:20189383 doi:10.1016/j.bmcl.2010.02.021
- Zobel K, Wang L, Varfolomeev E, Franklin MC, Elliott LO, Wallweber HJ, Okawa DC, Flygare JA, Vucic D, Fairbrother WJ, Deshayes K. Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs. ACS Chem Biol. 2006 Sep 19;1(8):525-33. PMID:17168540 doi:10.1021/cb600276q
- Vucic D, Franklin MC, Wallweber HJ, Das K, Eckelman BP, Shin H, Elliott LO, Kadkhodayan S, Deshayes K, Salvesen GS, Fairbrother WJ. Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP. Biochem J. 2005 Jan 1;385(Pt 1):11-20. PMID:15485396 doi:10.1042/BJ20041108
