2a4g

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[[Image:2a4g.png|left|200px]]
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{{STRUCTURE_2a4g| PDB=2a4g | SCENE= }}
{{STRUCTURE_2a4g| PDB=2a4g | SCENE= }}
===Hepatitis C Protease NS3-4A serine protease with Ketoamide Inhibitor SCH225724 Bound===
===Hepatitis C Protease NS3-4A serine protease with Ketoamide Inhibitor SCH225724 Bound===
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{{ABSTRACT_PUBMED_16087332}}
{{ABSTRACT_PUBMED_16087332}}
==About this Structure==
==About this Structure==
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[[2a4g]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A4G OCA].
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[[2a4g]] is a 4 chain structure of [[Helicase]] with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A4G OCA].
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==See Also==
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*[[Helicase|Helicase]]
==Reference==
==Reference==
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<ref group="xtra">PMID:16087332</ref><ref group="xtra">PMID:8861917</ref><ref group="xtra">PMID:8861916</ref><ref group="xtra">PMID:9568891</ref><ref group="xtra">PMID:10702283</ref><references group="xtra"/>
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<ref group="xtra">PMID:016087332</ref><ref group="xtra">PMID:008861917</ref><ref group="xtra">PMID:008861916</ref><ref group="xtra">PMID:009568891</ref><ref group="xtra">PMID:010702283</ref><references group="xtra"/>
[[Category: Hepatitis c virus]]
[[Category: Hepatitis c virus]]
[[Category: Arasappan, A.]]
[[Category: Arasappan, A.]]

Revision as of 13:04, 27 July 2012

Image:2a4g.png

Template:STRUCTURE 2a4g

Contents

Hepatitis C Protease NS3-4A serine protease with Ketoamide Inhibitor SCH225724 Bound

Template:ABSTRACT PUBMED 16087332

About this Structure

2a4g is a 4 chain structure of Helicase with sequence from Hepatitis c virus. Full crystallographic information is available from OCA.

See Also

Reference

  • Arasappan A, Njoroge FG, Chan TY, Bennett F, Bogen SL, Chen K, Gu H, Hong L, Jao E, Liu YT, Lovey RG, Parekh T, Pike RE, Pinto P, Santhanam B, Venkatraman S, Vaccaro H, Wang H, Yang X, Zhu Z, Mckittrick B, Saksena AK, Girijavallabhan V, Pichardo J, Butkiewicz N, Ingram R, Malcolm B, Prongay A, Yao N, Marten B, Madison V, Kemp S, Levy O, Lim-Wilby M, Tamura S, Ganguly AK. Hepatitis C virus NS3-4A serine protease inhibitors: SAR of P'2 moiety with improved potency. Bioorg Med Chem Lett. 2005 Oct 1;15(19):4180-4. PMID:16087332 doi:10.1016/j.bmcl.2005.06.091
  • Kim JL, Morgenstern KA, Lin C, Fox T, Dwyer MD, Landro JA, Chambers SP, Markland W, Lepre CA, O'Malley ET, Harbeson SL, Rice CM, Murcko MA, Caron PR, Thomson JA. Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide. Cell. 1996 Oct 18;87(2):343-55. PMID:8861917
  • Love RA, Parge HE, Wickersham JA, Hostomsky Z, Habuka N, Moomaw EW, Adachi T, Hostomska Z. The crystal structure of hepatitis C virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site. Cell. 1996 Oct 18;87(2):331-42. PMID:8861916
  • Yan Y, Li Y, Munshi S, Sardana V, Cole JL, Sardana M, Steinkuehler C, Tomei L, De Francesco R, Kuo LC, Chen Z. Complex of NS3 protease and NS4A peptide of BK strain hepatitis C virus: a 2.2 A resolution structure in a hexagonal crystal form. Protein Sci. 1998 Apr;7(4):837-47. PMID:9568891
  • Di Marco S, Rizzi M, Volpari C, Walsh MA, Narjes F, Colarusso S, De Francesco R, Matassa VG, Sollazzo M. Inhibition of the hepatitis C virus NS3/4A protease. The crystal structures of two protease-inhibitor complexes. J Biol Chem. 2000 Mar 10;275(10):7152-7. PMID:10702283

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