2ilm

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[[Image:2ilm.png|left|200px]]
[[Image:2ilm.png|left|200px]]
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{{STRUCTURE_2ilm| PDB=2ilm | SCENE= }}
{{STRUCTURE_2ilm| PDB=2ilm | SCENE= }}
===Factor Inhibiting HIF-1 Alpha D201A Mutant in Complex with FE(II), Alpha-Ketoglutarate and HIF-1 Alpha 35mer===
===Factor Inhibiting HIF-1 Alpha D201A Mutant in Complex with FE(II), Alpha-Ketoglutarate and HIF-1 Alpha 35mer===
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{{ABSTRACT_PUBMED_18611856}}
{{ABSTRACT_PUBMED_18611856}}
==About this Structure==
==About this Structure==
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[[2ilm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ILM OCA].
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[[2ilm]] is a 2 chain structure of [[Factor inhibiting HIF]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ILM OCA].
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==See Also==
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*[[Factor inhibiting HIF|Factor inhibiting HIF]]
==Reference==
==Reference==
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<ref group="xtra">PMID:18611856</ref><ref group="xtra">PMID:12446723</ref><ref group="xtra">PMID:15913349</ref><references group="xtra"/>
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<ref group="xtra">PMID:018611856</ref><ref group="xtra">PMID:012446723</ref><ref group="xtra">PMID:015913349</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Peptide-aspartate beta-dioxygenase]]
[[Category: Peptide-aspartate beta-dioxygenase]]

Revision as of 16:34, 26 July 2012

Image:2ilm.png

Template:STRUCTURE 2ilm

Contents

Factor Inhibiting HIF-1 Alpha D201A Mutant in Complex with FE(II), Alpha-Ketoglutarate and HIF-1 Alpha 35mer

Template:ABSTRACT PUBMED 18611856

About this Structure

2ilm is a 2 chain structure of Factor inhibiting HIF with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Hewitson KS, Holmes SL, Ehrismann D, Hardy AP, Chowdhury R, Schofield CJ, McDonough MA. Evidence that two enzyme-derived histidine ligands are sufficient for iron binding and catalysis by factor inhibiting HIF (FIH). J Biol Chem. 2008 Sep 19;283(38):25971-8. Epub 2008 Jul 8. PMID:18611856 doi:10.1074/jbc.M804999200
  • Elkins JM, Hewitson KS, McNeill LA, Seibel JF, Schlemminger I, Pugh CW, Ratcliffe PJ, Schofield CJ. Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha. J Biol Chem. 2003 Jan 17;278(3):1802-6. Epub 2002 Nov 21. PMID:12446723 doi:http://dx.doi.org/10.1074/jbc.C200644200
  • McDonough MA, McNeill LA, Tilliet M, Papamicael CA, Chen QY, Banerji B, Hewitson KS, Schofield CJ. Selective inhibition of factor inhibiting hypoxia-inducible factor. J Am Chem Soc. 2005 Jun 1;127(21):7680-1. PMID:15913349 doi:10.1021/ja050841b

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