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1v1k

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Revision as of 00:23, 15 March 2011

Image:1v1k.png

Template:STRUCTURE 1v1k

Contents

CDK2 IN COMPLEX WITH A DISUBSTITUTED 4, 6-BIS ANILINO PYRIMIDINE CDK4 INHIBITOR

Template:ABSTRACT PUBMED 12941311

About this Structure

1v1k is a 1 chain structure of Cell Division Protein Kinase 2 with sequence from Homo sapiens. This structure supersedes the now removed PDB entry 1h06. Full crystallographic information is available from OCA.

See Also

Reference

  • Beattie JF, Breault GA, Ellston RP, Green S, Jewsbury PJ, Midgley CJ, Naven RT, Minshull CA, Pauptit RA, Tucker JA, Pease JE. Cyclin-dependent kinase 4 inhibitors as a treatment for cancer. Part 1: identification and optimisation of substituted 4,6-bis anilino pyrimidines. Bioorg Med Chem Lett. 2003 Sep 15;13(18):2955-60. PMID:12941311
  • Schulze-Gahmen U, De Bondt HL, Kim SH. High-resolution crystal structures of human cyclin-dependent kinase 2 with and without ATP: bound waters and natural ligand as guides for inhibitor design. J Med Chem. 1996 Nov 8;39(23):4540-6. PMID:8917641 doi:10.1021/jm960402a

Proteopedia Page Contributors and Editors (what is this?)

OCA

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