1zp5

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[[Image:1zp5.png|left|200px]]
[[Image:1zp5.png|left|200px]]
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{{STRUCTURE_1zp5| PDB=1zp5 | SCENE= }}
{{STRUCTURE_1zp5| PDB=1zp5 | SCENE= }}
===Crystal structure of the complex between MMP-8 and a N-hydroxyurea inhibitor===
===Crystal structure of the complex between MMP-8 and a N-hydroxyurea inhibitor===
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{{ABSTRACT_PUBMED_16242329}}
{{ABSTRACT_PUBMED_16242329}}
==About this Structure==
==About this Structure==
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[[1zp5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZP5 OCA].
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[[1zp5]] is a 1 chain structure of [[Matrix metalloproteinase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZP5 OCA].
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==See Also==
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*[[Matrix metalloproteinase|Matrix metalloproteinase]]
==Reference==
==Reference==
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<ref group="xtra">PMID:16242329</ref><ref group="xtra">PMID:12171558</ref><ref group="xtra">PMID:7577999</ref><ref group="xtra">PMID:11412979</ref><references group="xtra"/>
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<ref group="xtra">PMID:016242329</ref><ref group="xtra">PMID:012171558</ref><ref group="xtra">PMID:007577999</ref><ref group="xtra">PMID:011412979</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Neutrophil collagenase]]
[[Category: Neutrophil collagenase]]

Revision as of 19:36, 25 July 2012

Image:1zp5.png

Template:STRUCTURE 1zp5

Contents

Crystal structure of the complex between MMP-8 and a N-hydroxyurea inhibitor

Template:ABSTRACT PUBMED 16242329

About this Structure

1zp5 is a 1 chain structure of Matrix metalloproteinase with sequence from Homo sapiens. Full crystallographic information is available from OCA.

See Also

Reference

  • Campestre C, Agamennone M, Tortorella P, Preziuso S, Biasone A, Gavuzzo E, Pochetti G, Mazza F, Hiller O, Tschesche H, Consalvi V, Gallina C. N-Hydroxyurea as zinc binding group in matrix metalloproteinase inhibition: mode of binding in a complex with MMP-8. Bioorg Med Chem Lett. 2006 Jan 1;16(1):20-4. Epub 2005 Oct 18. PMID:16242329 doi:10.1016/j.bmcl.2005.09.057
  • Muri EM, Nieto MJ, Sindelar RD, Williamson JS. Hydroxamic acids as pharmacological agents. Curr Med Chem. 2002 Sep;9(17):1631-53. PMID:12171558
  • Grams F, Crimmin M, Hinnes L, Huxley P, Pieper M, Tschesche H, Bode W. Structure determination and analysis of human neutrophil collagenase complexed with a hydroxamate inhibitor. Biochemistry. 1995 Oct 31;34(43):14012-20. PMID:7577999
  • Michaelides MR, Dellaria JF, Gong J, Holms JH, Bouska JJ, Stacey J, Wada CK, Heyman HR, Curtin ML, Guo Y, Goodfellow CL, Elmore IB, Albert DH, Magoc TJ, Marcotte PA, Morgan DW, Davidsen SK. Biaryl ether retrohydroxamates as potent, long-lived, orally bioavailable MMP inhibitors. Bioorg Med Chem Lett. 2001 Jun 18;11(12):1553-6. PMID:11412979

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