This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3mdm

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "3mdm" [edit=sysop:move=sysop])
Line 1: Line 1:
-
[[Image:3mdm.png|left|200px]]
 
- 
-
<!--
 
-
The line below this paragraph, containing "STRUCTURE_3mdm", creates the "Structure Box" on the page.
 
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
 
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
 
-
or leave the SCENE parameter empty for the default display.
 
-
-->
 
{{STRUCTURE_3mdm| PDB=3mdm | SCENE= }}
{{STRUCTURE_3mdm| PDB=3mdm | SCENE= }}
- 
===Thioperamide complex of Cytochrome P450 46A1===
===Thioperamide complex of Cytochrome P450 46A1===
 +
{{ABSTRACT_PUBMED_20667828}}
-
 
+
==Function==
-
<!--
+
[[http://www.uniprot.org/uniprot/CP46A_HUMAN CP46A_HUMAN]] Involved in the turnover of cholesterol. It converts cholesterol into 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol.
-
The line below this paragraph, {{ABSTRACT_PUBMED_20667828}}, adds the Publication Abstract to the page
+
-
(as it appears on PubMed at http://www.pubmed.gov), where 20667828 is the PubMed ID number.
+
-
-->
+
-
{{ABSTRACT_PUBMED_20667828}}
+
==About this Structure==
==About this Structure==
Line 22: Line 10:
==Reference==
==Reference==
-
<ref group="xtra">PMID:20667828</ref><ref group="xtra">PMID:18621681</ref><references group="xtra"/>
+
<ref group="xtra">PMID:020667828</ref><ref group="xtra">PMID:018621681</ref><references group="xtra"/><references/>
[[Category: Cholesterol 24-hydroxylase]]
[[Category: Cholesterol 24-hydroxylase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]

Revision as of 23:32, 10 April 2013

Template:STRUCTURE 3mdm

Contents

Thioperamide complex of Cytochrome P450 46A1

Template:ABSTRACT PUBMED 20667828

Function

[CP46A_HUMAN] Involved in the turnover of cholesterol. It converts cholesterol into 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol.

About this Structure

3mdm is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Mast N, Charvet C, Pikuleva IA, Stout CD. Structural basis of drug binding to CYP46A1, an enzyme that controls cholesterol turnover in the brain. J Biol Chem. 2010 Oct 8;285(41):31783-95. Epub 2010 Jul 28. PMID:20667828 doi:10.1074/jbc.M110.143313
  • Mast N, White MA, Bjorkhem I, Johnson EF, Stout CD, Pikuleva IA. Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain. Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9546-51. Epub 2008 Jul 9. PMID:18621681

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3mdm"
Personal tools