3p76

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[[Image:3p76.png|left|200px]]
 
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{{STRUCTURE_3p76| PDB=3p76 | SCENE= }}
{{STRUCTURE_3p76| PDB=3p76 | SCENE= }}
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===X-ray crystal structure of Aquifex aeolicus LpxC complexed SCH1379777===
===X-ray crystal structure of Aquifex aeolicus LpxC complexed SCH1379777===
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{{ABSTRACT_PUBMED_21273067}}
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==Function==
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[[http://www.uniprot.org/uniprot/LPXC_AQUAE LPXC_AQUAE]] Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity).
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(as it appears on PubMed at http://www.pubmed.gov), where 21273067 is the PubMed ID number.
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{{ABSTRACT_PUBMED_21273067}}
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==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:21273067</ref><references group="xtra"/>
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<ref group="xtra">PMID:021273067</ref><references group="xtra"/><references/>
[[Category: Aquifex aeolicus]]
[[Category: Aquifex aeolicus]]
[[Category: Orth, P.]]
[[Category: Orth, P.]]
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[[Category: Amidohydrolase]]
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[[Category: Amino acid motif]]
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[[Category: Binding site]]
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[[Category: Drug design]]
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[[Category: Enzyme inhibitor]]
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[[Category: Escherichia coli protein]]
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[[Category: Hydrolase]]
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[[Category: Hydrophobicity]]
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[[Category: Lipid some]]
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[[Category: Protein conformation]]
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[[Category: Protein folding]]
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[[Category: Recombinant fusion protein]]
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[[Category: Structure-activity relationship]]

Revision as of 08:23, 2 May 2013

Template:STRUCTURE 3p76

Contents

X-ray crystal structure of Aquifex aeolicus LpxC complexed SCH1379777

Template:ABSTRACT PUBMED 21273067

Function

[LPXC_AQUAE] Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity).

About this Structure

3p76 is a 1 chain structure with sequence from Aquifex aeolicus. Full crystallographic information is available from OCA.

Reference

  • Faruk Mansoor U, Vitharana D, Reddy PA, Daubaras DL, McNicholas P, Orth P, Black T, Arshad Siddiqui M. Design and synthesis of potent Gram-negative specific LpxC inhibitors. Bioorg Med Chem Lett. 2011 Feb 15;21(4):1155-61. Epub 2010 Dec 28. PMID:21273067 doi:10.1016/j.bmcl.2010.12.111

Proteopedia Page Contributors and Editors (what is this?)

OCA

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