Sandbox Reserved 313

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 7: Line 7:
=Introduction=
=Introduction=
'''Sphingomyelin phosphodiesterase''' (SMase) is an enzyme which catalyzes the hydrolysis of sphingomyelin to ceramide and phosphocholine <ref name="gp">PMID: 16595670 </ref>. There are 6 known types of sphingomyelinases:
'''Sphingomyelin phosphodiesterase''' (SMase) is an enzyme which catalyzes the hydrolysis of sphingomyelin to ceramide and phosphocholine <ref name="gp">PMID: 16595670 </ref>. There are 6 known types of sphingomyelinases:
-
==Acid sphingomyelinase (aSMase)==
+
''Acid sphingomyelinase (aSMase)''
-
==Secretory sphingomyelinase (sSMase)
+
''Secretory sphingomyelinase (sSMase)''
-
==Neutral, Mg2+-dependent sphingomyelinases (nSMase)==
+
''Neutral, Mg2+-dependent sphingomyelinases (nSMase)''
-
==Mg2+-independent neutral sphingomyelinases.==
+
''Mg2+-independent neutral sphingomyelinases''
-
==Alkaline sphingomyelinase==
+
''Alkaline sphingomyelinase''
-
==Bacterial sphingomyelinase==
+
''Bacterial sphingomyelinase''
=Structure and Function=
=Structure and Function=
=Mechanism=
=Mechanism=

Revision as of 04:24, 17 March 2011

This Sandbox is Reserved from January 10, 2010, through April 10, 2011 for use in BCMB 307-Proteins course taught by Andrea Gorrell at the University of Northern British Columbia, Prince George, BC, Canada.
To get started:
  • Click the edit this page tab at the top. Save the page after each step, then edit it again.
  • Click the 3D button (when editing, above the wikitext box) to insert Jmol.
  • show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page.
  • Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc.

More help: Help:Editing


PDB ID 2dds

Drag the structure with the mouse to rotate
2dds, resolution 1.80Å ()
Ligands:
Activity: Sphingomyelin phosphodiesterase, with EC number 3.1.4.12
Related: 2ddr, 2ddt
Resources: FirstGlance, OCA, PDBsum, RCSB, TOPSAN
Coordinates: save as pdb, mmCIF, xml


Contents

Introduction

Sphingomyelin phosphodiesterase (SMase) is an enzyme which catalyzes the hydrolysis of sphingomyelin to ceramide and phosphocholine [1]. There are 6 known types of sphingomyelinases: Acid sphingomyelinase (aSMase) Secretory sphingomyelinase (sSMase) Neutral, Mg2+-dependent sphingomyelinases (nSMase) Mg2+-independent neutral sphingomyelinases Alkaline sphingomyelinase Bacterial sphingomyelinase

Structure and Function

Mechanism

Importance of SMase

References

  1. ↑ Ago H, Oda M, Takahashi M, Tsuge H, Ochi S, Katunuma N, Miyano M, Sakurai J. Structural basis of the sphingomyelin phosphodiesterase activity in neutral sphingomyelinase from Bacillus cereus. J Biol Chem. 2006 Jun 9;281(23):16157-67. Epub 2006 Apr 4. PMID:16595670 doi:10.1074/jbc.M601089200
Retrieved from "http://52.214.119.220/wiki/index.php/Sandbox_Reserved_313"
Personal tools