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Sandbox Reserved 313

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=Introduction=
=Introduction=
'''Sphingomyelin phosphodiesterase''' (SMase) is an enzyme which catalyzes the hydrolysis of sphingomyelin to ceramide and phosphocholine <ref name="gp">PMID: 16595670 </ref>. There are 6 known types of sphingomyelinases:
'''Sphingomyelin phosphodiesterase''' (SMase) is an enzyme which catalyzes the hydrolysis of sphingomyelin to ceramide and phosphocholine <ref name="gp">PMID: 16595670 </ref>. There are 6 known types of sphingomyelinases:
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''Acid sphingomyelinase (aSMase)''
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''Acid sphingomyelinase (aSMase)'' -
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''Secretory sphingomyelinase (sSMase)''
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''Secretory sphingomyelinase (sSMase)'' -
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''Neutral, Mg2+-dependent sphingomyelinases (nSMase)''
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''Neutral, Mg2+-dependent sphingomyelinases (nSMase)'' -
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''Mg2+-independent neutral sphingomyelinases''
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''Mg2+-independent neutral sphingomyelinases'' -
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''Alkaline sphingomyelinase''
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''Alkaline sphingomyelinase'' -
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''Bacterial sphingomyelinase''
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''Bacterial sphingomyelinase'' -
=Structure and Function=
=Structure and Function=
=Mechanism=
=Mechanism=

Revision as of 04:29, 17 March 2011

This Sandbox is Reserved from January 10, 2010, through April 10, 2011 for use in BCMB 307-Proteins course taught by Andrea Gorrell at the University of Northern British Columbia, Prince George, BC, Canada.
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PDB ID 2dds

Drag the structure with the mouse to rotate
2dds, resolution 1.80Å ()
Ligands:
Activity: Sphingomyelin phosphodiesterase, with EC number 3.1.4.12
Related: 2ddr, 2ddt
Resources: FirstGlance, OCA, PDBsum, RCSB, TOPSAN
Coordinates: save as pdb, mmCIF, xml


Contents

Introduction

Sphingomyelin phosphodiesterase (SMase) is an enzyme which catalyzes the hydrolysis of sphingomyelin to ceramide and phosphocholine [1]. There are 6 known types of sphingomyelinases: Acid sphingomyelinase (aSMase) - Secretory sphingomyelinase (sSMase) - Neutral, Mg2+-dependent sphingomyelinases (nSMase) - Mg2+-independent neutral sphingomyelinases - Alkaline sphingomyelinase - Bacterial sphingomyelinase -

Structure and Function

Mechanism

Importance of SMase

References

  1. ↑ Ago H, Oda M, Takahashi M, Tsuge H, Ochi S, Katunuma N, Miyano M, Sakurai J. Structural basis of the sphingomyelin phosphodiesterase activity in neutral sphingomyelinase from Bacillus cereus. J Biol Chem. 2006 Jun 9;281(23):16157-67. Epub 2006 Apr 4. PMID:16595670 doi:10.1074/jbc.M601089200
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