Sandbox Reserved 313

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{{STRUCTURE_2dds | PDB=2dds | SCENE=Sandbox_Reserved_313/2dds/1}}
{{STRUCTURE_2dds | PDB=2dds | SCENE=Sandbox_Reserved_313/2dds/1}}
=Introduction=
=Introduction=
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'''Sphingomyelin phosphodiesterase''' (SMase) is an enzyme which catalyzes the hydrolysis of sphingomyelin to ceramide and phosphocholine <ref name="gp">PMID: 16595670 </ref>. There are 6 known types of sphingomyelinases<ref name="gp2">PMID: 12401200 </ref>. :
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'''Sphingomyelin phosphodiesterase''' (SMase) is an enzyme which catalyzes the hydrolysis of sphingomyelin to ceramide and phosphocholine <ref name="gp">PMID: 16595670 </ref>. This enzyme has become the object of renewed interest since the discovery of the sphingomyelin signal transduction pathway which is involved in apoptosis. This pathway is initiated by sphingomyelinase hydrolysis of sphingomyelin in the plasma membrane to generate ceramide. Ceramide acts as a secondary messenger which causes the stimulation of the cascade effect of kinases and transcription factors which activate programmed cell death<ref name="gp2">PMID: 7544586 </ref>. There are 6 known types of sphingomyelinases<ref name="gp3">PMID: 12401200 </ref>. :
''Acid sphingomyelinase (aSMase)'' -
''Acid sphingomyelinase (aSMase)'' -

Revision as of 04:55, 17 March 2011

This Sandbox is Reserved from January 10, 2010, through April 10, 2011 for use in BCMB 307-Proteins course taught by Andrea Gorrell at the University of Northern British Columbia, Prince George, BC, Canada.
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PDB ID 2dds

Drag the structure with the mouse to rotate
2dds, resolution 1.80Å ()
Ligands:
Activity: Sphingomyelin phosphodiesterase, with EC number 3.1.4.12
Related: 2ddr, 2ddt
Resources: FirstGlance, OCA, PDBsum, RCSB, TOPSAN
Coordinates: save as pdb, mmCIF, xml


Contents

Introduction

Sphingomyelin phosphodiesterase (SMase) is an enzyme which catalyzes the hydrolysis of sphingomyelin to ceramide and phosphocholine [1]. This enzyme has become the object of renewed interest since the discovery of the sphingomyelin signal transduction pathway which is involved in apoptosis. This pathway is initiated by sphingomyelinase hydrolysis of sphingomyelin in the plasma membrane to generate ceramide. Ceramide acts as a secondary messenger which causes the stimulation of the cascade effect of kinases and transcription factors which activate programmed cell death[2]. There are 6 known types of sphingomyelinases[3]. :

Acid sphingomyelinase (aSMase) -

Secretory sphingomyelinase (sSMase) -

Neutral, Mg2+-dependent sphingomyelinases (nSMase) -

Mg2+-independent neutral sphingomyelinases -

Alkaline sphingomyelinase -

Bacterial sphingomyelinase -

Structure and Function

Mechanism

Importance of SMase

References

  1. ↑ Ago H, Oda M, Takahashi M, Tsuge H, Ochi S, Katunuma N, Miyano M, Sakurai J. Structural basis of the sphingomyelin phosphodiesterase activity in neutral sphingomyelinase from Bacillus cereus. J Biol Chem. 2006 Jun 9;281(23):16157-67. Epub 2006 Apr 4. PMID:16595670 doi:10.1074/jbc.M601089200
  2. ↑ Kolesnick RN, Haimovitz-Friedman A, Fuks Z. The sphingomyelin signal transduction pathway mediates apoptosis for tumor necrosis factor, Fas, and ionizing radiation. Biochem Cell Biol. 1994 Nov-Dec;72(11-12):471-4. PMID:7544586
  3. ↑ Goni FM, Alonso A. Sphingomyelinases: enzymology and membrane activity. FEBS Lett. 2002 Oct 30;531(1):38-46. PMID:12401200
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