Nucleoporin
From Proteopedia
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[[Image:1xip.png|left|200px|thumb|Crystal structure of the N-terminal domain of yeast Nucleoporin NUP159, [[1xip]]]] | [[Image:1xip.png|left|200px|thumb|Crystal structure of the N-terminal domain of yeast Nucleoporin NUP159, [[1xip]]]] | ||
{{STRUCTURE_1xip| PDB=1xip | SIZE=300| SCENE=Nucleoporin/Cv/1 |right|CAPTION=yeast Nucleoporin NUP159, [[1xip]] }} | {{STRUCTURE_1xip| PDB=1xip | SIZE=300| SCENE=Nucleoporin/Cv/1 |right|CAPTION=yeast Nucleoporin NUP159, [[1xip]] }} | ||
| - | [[Nucleoporin|Nucleoporins]] (NUP) are constituents of the nuclear pore complex which regulates the flow of macromolecules across the nuclear envelope. They are named according to their molecular weights. They contain a domain which binds the protein RAN (RANBD). The images at the left and at the right correspond to one representative Nucleoporin structure, ''i.e.'' crystal structure of yeast Nucleoporin NUP159 from ''Saccharomyces cerevisiae'' ([[1xip]]), | + | [[Nucleoporin|Nucleoporins]] (NUP) are constituents of the nuclear pore complex which regulates the flow of macromolecules across the nuclear envelope. They are named according to their molecular weights. They contain a domain which binds the protein RAN (RANBD), N-terminal domain (NTD) and C-terminal domain (CTD). The images at the left and at the right correspond to one representative Nucleoporin structure, ''i.e.'' crystal structure of yeast Nucleoporin NUP159 from ''Saccharomyces cerevisiae'' ([[1xip]]), |
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== 3D Structures of Nucleoporin == | == 3D Structures of Nucleoporin == | ||
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| + | ''Updated December 2011'' | ||
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==NUP2== | ==NUP2== | ||
[[3n7c]] – NUP2 RANBD – ''Ashbya gossypii''<br /> | [[3n7c]] – NUP2 RANBD – ''Ashbya gossypii''<br /> | ||
| - | [[2c1t]] – yNUP2 | + | [[2c1t]] – yNUP2 NTD +importrin alpha subunit - yeast<br /> |
==NUP35== | ==NUP35== | ||
[[1wwh]] – mNUP35 MPPN domain - mouse<br /> | [[1wwh]] – mNUP35 MPPN domain - mouse<br /> | ||
==NUP50== | ==NUP50== | ||
[[2ec1]] – hNUP50 RANBD - human<br /> | [[2ec1]] – hNUP50 RANBD - human<br /> | ||
| - | [[2c1m]] – mNUP50 | + | [[2c1m]] – mNUP50 NTD +importin <br /> |
==NUP53== | ==NUP53== | ||
| - | [[3p3d]] - NUP53 RRM domain - Pischia guillermondii | + | [[3p3d]] - NUP53 RRM domain - ''Pischia guillermondii'' |
| + | ==NUP54== | ||
| + | [[3t97]] – rNUP54 + NUP62 - rat<br /> | ||
==NUP58== | ==NUP58== | ||
| - | [[2osz]] – rNUP58/45 | + | [[2osz]] – rNUP58/45 <br /> |
| + | ==NUP82== | ||
| + | [[3pbp]] – yNUP82 NTD + NUP116 CTD + NUP159 tail<br /> | ||
==NUP84== | ==NUP84== | ||
[[3jro]], [[3iko]] – yNUP84+NUP145+protein Sec13<br /> | [[3jro]], [[3iko]] – yNUP84+NUP145+protein Sec13<br /> | ||
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==NUP98== | ==NUP98== | ||
[[3mmy]] – hNUP98 fragment+mRNA export factor <br /> | [[3mmy]] – hNUP98 fragment+mRNA export factor <br /> | ||
| - | [[2q5x]], [[2q5y]] – hNUP98 | + | [[2q5x]], [[2q5y]] – hNUP98 CTD<br /> |
| - | [[1ko6]] – hNUP98 | + | [[1ko6]] – hNUP98 CTD<br /> |
==NUP100== | ==NUP100== | ||
| - | [[3nf5]] – NUP100 | + | [[3nf5]] – NUP100 CTD – ''Candida glabrata''<br /> |
==NUP107== | ==NUP107== | ||
[[3i4r]], [[3cqc]], [[3cqg]] – hNUP107+NUP133<br /> | [[3i4r]], [[3cqc]], [[3cqg]] – hNUP107+NUP133<br /> | ||
==NUP116== | ==NUP116== | ||
| - | [[2aiv]] – yNUP116 | + | [[2aiv]] – yNUP116 CTD - NMR<br /> |
==NUP120== | ==NUP120== | ||
[[3f7f]], [[3h7n]], [[3hxr]] – yNUP120<br /> | [[3f7f]], [[3h7n]], [[3hxr]] – yNUP120<br /> | ||
==NUP133== | ==NUP133== | ||
| - | [[1xks]] – hNUP133 | + | [[1xks]] – hNUP133 NTD<br /> |
| - | [[3kfo]] – yNUP133 | + | [[3kfo]] – yNUP133 CTD <br /> |
==NUP145== | ==NUP145== | ||
[[3bg0]], [[3bg1]] – hNUP145+Sec13-related protein<br /> | [[3bg0]], [[3bg1]] – hNUP145+Sec13-related protein<br /> | ||
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[[2k0c]] – rNUP153 RANBD – NMR<br /> | [[2k0c]] – rNUP153 RANBD – NMR<br /> | ||
==NUP159== | ==NUP159== | ||
| - | [[1xip]] – yNUP159 | + | [[1xip]] – yNUP159 NTD<br /> |
| + | [[3rrm]] – yNUP159 residues 2-387 + NUP Gle1 + IP6 + ADP<br /> | ||
==NUP170== | ==NUP170== | ||
[[3i5p]], [[3i5q]] – yNUP170<br /> | [[3i5p]], [[3i5q]] – yNUP170<br /> | ||
==NUP214== | ==NUP214== | ||
[[3fmo]], [[3fmp]], [[3fhc]] – hNUP214+dead-box helicase<br /> | [[3fmo]], [[3fmp]], [[3fhc]] – hNUP214+dead-box helicase<br /> | ||
| - | [[2oit]] – hNUP214 | + | [[2oit]] – hNUP214 NTD<br /> |
==NUP358== | ==NUP358== | ||
| - | [[1z5s]] – hNUP358 IR1 domain+ubiquitin-conjugating enzyme+SMT3C+RAN | + | [[1z5s]] – hNUP358 IR1 domain+ubiquitin-conjugating enzyme+SMT3C+RAN CTD<br /> |
[[1xke]] - hNUP358 RANBD - NMR<br /> | [[1xke]] - hNUP358 RANBD - NMR<br /> | ||
==NUP1P== | ==NUP1P== | ||
[[2bpt]] – yNUP1P+importin β subunit<br /> | [[2bpt]] – yNUP1P+importin β subunit<br /> | ||
==NUP2P== | ==NUP2P== | ||
| - | [[1un0]] – yNUP2P | + | [[1un0]] – yNUP2P NTD+importrin α subunit<br /> |
==NUP-NSP1== | ==NUP-NSP1== | ||
[[1o6o]] – yNUP-NSP1 residues 497-608+importrin β subunit<br /> | [[1o6o]] – yNUP-NSP1 residues 497-608+importrin β subunit<br /> | ||
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[[2doq]], [[2gv5]] – yNUP-CDC31+SFI1P<br /> | [[2doq]], [[2gv5]] – yNUP-CDC31+SFI1P<br /> | ||
[[3fwb]], [[3fwc]] - yNUP-CDC31+SAC3<br /> | [[3fwb]], [[3fwc]] - yNUP-CDC31+SAC3<br /> | ||
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| + | ==NUP Gle1== | ||
| + | [[3peu]], [[3pev]], [[3rrn]]– yNUP-Gle1 + ATP-dependent RNA helicase Dbp5 (mutant) +IP6 | ||
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[[2rfo]], [[2qx5]] – yNic96<br /> | [[2rfo]], [[2qx5]] – yNic96<br /> | ||
[[1gyb]] – NUP+yNTF2<br /> | [[1gyb]] – NUP+yNTF2<br /> | ||
Revision as of 09:18, 6 December 2011
Template:STRUCTURE 1xip Nucleoporins (NUP) are constituents of the nuclear pore complex which regulates the flow of macromolecules across the nuclear envelope. They are named according to their molecular weights. They contain a domain which binds the protein RAN (RANBD), N-terminal domain (NTD) and C-terminal domain (CTD). The images at the left and at the right correspond to one representative Nucleoporin structure, i.e. crystal structure of yeast Nucleoporin NUP159 from Saccharomyces cerevisiae (1xip),
Contents |
3D Structures of Nucleoporin
Updated December 2011
NUP2
3n7c – NUP2 RANBD – Ashbya gossypii
2c1t – yNUP2 NTD +importrin alpha subunit - yeast
NUP35
1wwh – mNUP35 MPPN domain - mouse
NUP50
2ec1 – hNUP50 RANBD - human
2c1m – mNUP50 NTD +importin
NUP53
3p3d - NUP53 RRM domain - Pischia guillermondii
NUP54
3t97 – rNUP54 + NUP62 - rat
NUP58
2osz – rNUP58/45
NUP82
3pbp – yNUP82 NTD + NUP116 CTD + NUP159 tail
NUP84
3jro, 3iko – yNUP84+NUP145+protein Sec13
NUP85
3f3f, 3f3g, 3f3p, 3ewe – yNUP85+Seh1
NUP98
3mmy – hNUP98 fragment+mRNA export factor
2q5x, 2q5y – hNUP98 CTD
1ko6 – hNUP98 CTD
NUP100
3nf5 – NUP100 CTD – Candida glabrata
NUP107
3i4r, 3cqc, 3cqg – hNUP107+NUP133
NUP116
2aiv – yNUP116 CTD - NMR
NUP120
NUP133
1xks – hNUP133 NTD
3kfo – yNUP133 CTD
NUP145
3bg0, 3bg1 – hNUP145+Sec13-related protein
3kep, 3kes – yNUP145 autoproteolytic domain
3jrp - yNUP145+protein Sec13
NUP153
3gj3, 3gj4, 3gj5, 3gj6, 3gj7, 3gj8, 3ch5 – hNUP153+RAN
2ebq, 2ebr, 2ebv, 2gqe - hNUP153 RANBD – NMR
2k0c – rNUP153 RANBD – NMR
NUP159
1xip – yNUP159 NTD
3rrm – yNUP159 residues 2-387 + NUP Gle1 + IP6 + ADP
NUP170
NUP214
3fmo, 3fmp, 3fhc – hNUP214+dead-box helicase
2oit – hNUP214 NTD
NUP358
1z5s – hNUP358 IR1 domain+ubiquitin-conjugating enzyme+SMT3C+RAN CTD
1xke - hNUP358 RANBD - NMR
NUP1P
2bpt – yNUP1P+importin β subunit
NUP2P
1un0 – yNUP2P NTD+importrin α subunit
NUP-NSP1
1o6o – yNUP-NSP1 residues 497-608+importrin β subunit
NUP-CDC31
2doq, 2gv5 – yNUP-CDC31+SFI1P
3fwb, 3fwc - yNUP-CDC31+SAC3
NUP Gle1
3peu, 3pev, 3rrn– yNUP-Gle1 + ATP-dependent RNA helicase Dbp5 (mutant) +IP6
2rfo, 2qx5 – yNic96
1gyb – NUP+yNTF2
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Joel L. Sussman, Alexander Berchansky, Jaime Prilusky
