Sandbox Reserved 196

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== Background ==
== Background ==
2D pic (left)
2D pic (left)
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[[Image:RNaseB.png | thumb ]]
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[[Image:RNaseB.png | thumb|left|RNase B]]
3D pic (Right)
3D pic (Right)
have at least 2 green links
have at least 2 green links
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<Structure load='1rbb' size='500' frame='true' align='right' caption='Insert caption here' scene='Sandbox_Reserved_196/Rbb_basic/1' />
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<Structure load='1rbb' size='300' frame='true' align='right' caption='Insert caption here' scene='Sandbox_Reserved_196/Rbb_basic/1' />
== Biology of RNase B ==
== Biology of RNase B ==
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<ref group=>PMID:3680242</ref><references />
<ref group=>PMID:3680242</ref><references />
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<Structure load='1rbj' size='500' frame='true' align='right' caption='Ribonuclease B with a strand of DNA in active site' scene='Sandbox_Reserved_196/Secondary_structure/4' />
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<Structure load='1rbj' size='300' frame='true' align='right' caption='Ribonuclease B with a strand of DNA in active site' scene='Sandbox_Reserved_196/Secondary_structure/4' />

Revision as of 19:08, 28 March 2011

This Sandbox is Reserved from Feb 02, 2011, through Jul 31, 2011 for use by the Biochemistry II class at the Butler University at Indianapolis, IN USA taught by R. Jeremy Johnson. This reservation includes Sandbox Reserved 191 through Sandbox Reserved 200.
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Contents

Ribonuclease B (RNase B)

Introduction

Ribonuclease B is structurally the same as RNase A. However is has an additional catalytic activity caused by the attachment of polysaccharrides at the Asn-34. This small change allows RNase B to hydrolyze double-stranded RNA at ionic strengths where RNase A has no activity. This shows that small changes in the active sites of very similar molecules can lead to todally new roles and activities.

Background 

  2D pic (left)
Image:RNaseB.png
RNase B
  3D pic (Right)
   have at least 2 green links

Insert caption here

Drag the structure with the mouse to rotate

Biology of RNase B 

 green links

Description

References

[1]
  1. ↑ Williams RL, Greene SM, McPherson A. The crystal structure of ribonuclease B at 2.5-A resolution. J Biol Chem. 1987 Nov 25;262(33):16020-31. PMID:3680242

Ribonuclease B with a strand of DNA in active site

Drag the structure with the mouse to rotate


Additional Resources

  • Dr. Johnson
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