Sandbox Reserved 168

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== SKI protein ==
== SKI protein ==
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<Structure load='1sbx' size='500' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /><!-- PLEASE DO NOT DELETE THIS TEMPLATE -->
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<Structure load='1sbx' size='500' frame='true' align='right' caption='Crystal Structure of human SKI, PDB ID: 1SBX' scene='Insert optional scene name here' /><!-- PLEASE DO NOT DELETE THIS TEMPLATE -->
{{Sandbox_Reserved_Irma_Santoro_7}}
{{Sandbox_Reserved_Irma_Santoro_7}}
<!-- PLEASE ADD YOUR CONTENT BELOW HERE -->
<!-- PLEASE ADD YOUR CONTENT BELOW HERE -->
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== Background ==
== Background ==
A proto-oncoprotein is a gene that can become an oncogene, or a gene that has the potential to cause cancer if mutated or if expressed in quantitative amounts. The SKI protein acts as said protooncogene. Although The SKI protein has been associated with tumors at large levels of cellular concentrations and it has been shown to interfere with normal cellular functioning.
A proto-oncoprotein is a gene that can become an oncogene, or a gene that has the potential to cause cancer if mutated or if expressed in quantitative amounts. The SKI protein acts as said protooncogene. Although The SKI protein has been associated with tumors at large levels of cellular concentrations and it has been shown to interfere with normal cellular functioning.
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<ref name="SKI protein"> Reed JA, Lin Q, Chen D, Mian IS, Medrano EE. SKI Pathways Inducing Progression of Human Melanoma. June 2005. http://www.ncbi.nlm.nih.gov/pubmed/15986136</ref>.
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<ref name="SKI protein"> Reed JA, Lin Q, Chen D, Mian IS, Medrano EE. SKI Pathways Inducing Progression of Human Melanoma. June 2005. http://www.ncbi.nlm.nih.gov/pubmed/15986136</ref>.
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<ref name="SKI protein"> Colmenares C, Heilstedt HA, Shaffer LG, Schwartz S, Berk M, Murray JC,, and Stavnezer E. 2006. Nat. Genet., 30, 106-109>.
 
== Structure ==
== Structure ==
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Revision as of 20:05, 29 March 2011

Contents

SKI protein

Crystal Structure of human SKI, PDB ID: 1SBX

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This Sandbox is Reserved from March 9, 2011, through May 30, 2011 for use by the course Biochemistry at Reinhardt University, Waleska, USA, taught by Irma Santoro. This reservation includes Sandbox Reserved 162 through Sandbox Reserved 168.
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Background

A proto-oncoprotein is a gene that can become an oncogene, or a gene that has the potential to cause cancer if mutated or if expressed in quantitative amounts. The SKI protein acts as said protooncogene. Although The SKI protein has been associated with tumors at large levels of cellular concentrations and it has been shown to interfere with normal cellular functioning. [1].


Structure

References

  1. ↑ Reed JA, Lin Q, Chen D, Mian IS, Medrano EE. SKI Pathways Inducing Progression of Human Melanoma. June 2005. http://www.ncbi.nlm.nih.gov/pubmed/15986136
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