3qgb
From Proteopedia
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{{STRUCTURE_3qgb| PDB=3qgb | SCENE= }} | {{STRUCTURE_3qgb| PDB=3qgb | SCENE= }} | ||
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===Crystal structure of FBF-2 R288Y mutant in complex with gld-1 FBEa=== | ===Crystal structure of FBF-2 R288Y mutant in complex with gld-1 FBEa=== | ||
+ | {{ABSTRACT_PUBMED_21372189}} | ||
- | + | ==Function== | |
- | + | [[http://www.uniprot.org/uniprot/FBF2_CAEEL FBF2_CAEEL]] Involved in the control of stem cells and sex determination in the C.elegans hermaphrodite germline. May also play a role in the hermaphrodite germline proliferation and oogenesis. Binds specifically to the regulatory region of fem-3 3'-UTR and mediates the sperm/oocyte switch. Negatively regulates gld-3 expression possibly by directly binding to two sites within the gld-3 isoform B 3'-UTR.<ref>PMID:9393998</ref> <ref>PMID:15454534</ref> | |
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==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
- | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:021372189</ref><references group="xtra"/><references/> |
[[Category: Caenorhabditis elegans]] | [[Category: Caenorhabditis elegans]] | ||
[[Category: Gross, L.]] | [[Category: Gross, L.]] | ||
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[[Category: Wang, Y.]] | [[Category: Wang, Y.]] | ||
[[Category: Wickens, M.]] | [[Category: Wickens, M.]] | ||
+ | [[Category: Base stacking]] | ||
+ | [[Category: Fbf]] | ||
+ | [[Category: Fem-3 binding factor]] | ||
+ | [[Category: Puf]] | ||
+ | [[Category: Rna binding protein-rna complex]] | ||
+ | [[Category: Rna-binding specificity]] |
Revision as of 08:09, 8 May 2013
Contents |
Crystal structure of FBF-2 R288Y mutant in complex with gld-1 FBEa
Template:ABSTRACT PUBMED 21372189
Function
[FBF2_CAEEL] Involved in the control of stem cells and sex determination in the C.elegans hermaphrodite germline. May also play a role in the hermaphrodite germline proliferation and oogenesis. Binds specifically to the regulatory region of fem-3 3'-UTR and mediates the sperm/oocyte switch. Negatively regulates gld-3 expression possibly by directly binding to two sites within the gld-3 isoform B 3'-UTR.[1] [2]
About this Structure
3qgb is a 2 chain structure with sequence from Caenorhabditis elegans. Full crystallographic information is available from OCA.
Reference
- Koh YY, Wang Y, Qiu C, Opperman L, Gross L, Tanaka Hall TM, Wickens M. Stacking interactions in PUF-RNA complexes. RNA. 2011 Apr;17(4):718-27. Epub 2011 Mar 3. PMID:21372189 doi:10.1261/rna.2540311
- ↑ Zhang B, Gallegos M, Puoti A, Durkin E, Fields S, Kimble J, Wickens MP. A conserved RNA-binding protein that regulates sexual fates in the C. elegans hermaphrodite germ line. Nature. 1997 Dec 4;390(6659):477-84. PMID:9393998 doi:10.1038/37297
- ↑ Eckmann CR, Crittenden SL, Suh N, Kimble J. GLD-3 and control of the mitosis/meiosis decision in the germline of Caenorhabditis elegans. Genetics. 2004 Sep;168(1):147-60. PMID:15454534 doi:10.1534/genetics.104.029264