3op8

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[[Image:3op8.png|left|200px]]
 
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{{STRUCTURE_3op8| PDB=3op8 | SCENE= }}
{{STRUCTURE_3op8| PDB=3op8 | SCENE= }}
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===Crystal structure of the domain V from beta2-glycoprotein I===
===Crystal structure of the domain V from beta2-glycoprotein I===
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{{ABSTRACT_PUBMED_21179511}}
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==Function==
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[[http://www.uniprot.org/uniprot/APOH_HUMAN APOH_HUMAN]] Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.
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(as it appears on PubMed at http://www.pubmed.gov), where 21179511 is the PubMed ID number.
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{{ABSTRACT_PUBMED_21179511}}
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==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:21179511</ref><references group="xtra"/>
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<ref group="xtra">PMID:021179511</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Beglova, N.]]
[[Category: Beglova, N.]]
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[[Category: Kolyada, A.]]
[[Category: Kolyada, A.]]
[[Category: Lee, C J.]]
[[Category: Lee, C J.]]
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[[Category: Anionic phospholipids binding]]
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[[Category: Antiphospholipid syndrome]]
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[[Category: Blood plasma]]
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[[Category: Lipoprotein receptors binding]]
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[[Category: Protein binding]]
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[[Category: Sushi]]

Revision as of 08:35, 2 May 2013

Template:STRUCTURE 3op8

Contents

Crystal structure of the domain V from beta2-glycoprotein I

Template:ABSTRACT PUBMED 21179511

Function

[APOH_HUMAN] Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.

About this Structure

3op8 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Kolyada A, Lee CJ, De Biasio A, Beglova N. A Novel Dimeric Inhibitor Targeting Beta2GPI in Beta2GPI/Antibody Complexes Implicated in Antiphospholipid Syndrome. PLoS One. 2010 Dec 15;5(12):e15345. PMID:21179511 doi:10.1371/journal.pone.0015345

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OCA

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