We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

1okx

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 26: Line 26:
[[Category: protease]]
[[Category: protease]]
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:49:45 2007''
+
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 15:57:32 2007''

Revision as of 13:52, 30 October 2007

Image:1okx.gif

1okx, resolution 2.80Å

Drag the structure with the mouse to rotate

BINDING STRUCTURE OF ELASTASE INHIBITOR SCYPTOLIN A

Overview

Natural bioactive compounds are of general interest to pharmaceutical, research because they may be used as leads in drug development campaigns., Among them, scyptolin A and B from Scytonema hofmanni PCC 7110 are known, to inhibit porcine pancreatic elastase, which in turn resembles the, attractive drug target neutrophil elastase. The crystal structure of, scyptolin A as bound to pancreatic elastase was solved at 2.8 A, resolution. The inhibitor occupies the most prominent subsites S1 through, S4 of the elastase and prevents a hydrolytic attack by covering the active, center with its rigid ring structure. The observed binding structure may, help to design potent elastase inhibitors.

About this Structure

1OKX is a [Protein complex] structure of sequences from [Scytonema hofmanni] and [Sus scrofa]. Active as [Pancreatic elastase], with EC number [3.4.21.36]. Structure known Active Site: SC1. Full crystallographic information is available from [OCA].

Reference

Binding structure of elastase inhibitor scyptolin A., Matern U, Schleberger C, Jelakovic S, Weckesser J, Schulz GE, Chem Biol. 2003 Oct;10(10):997-1001. PMID:14583266

Page seeded by OCA on Tue Oct 30 15:57:32 2007

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1okx"
Personal tools