3o0u
From Proteopedia
(Difference between revisions)
m (Protected "3o0u" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:3o0u. | + | [[Image:3o0u.png|left|200px]] |
| - | <!-- | ||
| - | The line below this paragraph, containing "STRUCTURE_3o0u", creates the "Structure Box" on the page. | ||
| - | You may change the PDB parameter (which sets the PDB file loaded into the applet) | ||
| - | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | ||
| - | or leave the SCENE parameter empty for the default display. | ||
| - | --> | ||
{{STRUCTURE_3o0u| PDB=3o0u | SCENE= }} | {{STRUCTURE_3o0u| PDB=3o0u | SCENE= }} | ||
===Cathepsin K covalently bound to a cyano-pyrimidine inhibitor with improved selectivity over hERG=== | ===Cathepsin K covalently bound to a cyano-pyrimidine inhibitor with improved selectivity over hERG=== | ||
| - | |||
| - | <!-- | ||
| - | The line below this paragraph, {{ABSTRACT_PUBMED_20843687}}, adds the Publication Abstract to the page | ||
| - | (as it appears on PubMed at http://www.pubmed.gov), where 20843687 is the PubMed ID number. | ||
| - | --> | ||
{{ABSTRACT_PUBMED_20843687}} | {{ABSTRACT_PUBMED_20843687}} | ||
==About this Structure== | ==About this Structure== | ||
| - | [[3o0u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O0U OCA]. | + | [[3o0u]] is a 1 chain structure of [[Cathepsin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O0U OCA]. |
| + | |||
| + | ==See Also== | ||
| + | *[[Cathepsin|Cathepsin]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:020843687</ref><references group="xtra"/> |
[[Category: Cathepsin K]] | [[Category: Cathepsin K]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| Line 28: | Line 20: | ||
[[Category: Uitdehaag, J C.M.]] | [[Category: Uitdehaag, J C.M.]] | ||
[[Category: Zeeland, M van.]] | [[Category: Zeeland, M van.]] | ||
| + | [[Category: Bone]] | ||
| + | [[Category: Covalent 2-cyano-pyrimidine inhibitor]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Hydrolase-hydrolase inhibitor complex]] | ||
| + | [[Category: Reversible covalent bond between cys25 and ligand]] | ||
Revision as of 10:05, 25 July 2012
Contents |
Cathepsin K covalently bound to a cyano-pyrimidine inhibitor with improved selectivity over hERG
Template:ABSTRACT PUBMED 20843687
About this Structure
3o0u is a 1 chain structure of Cathepsin with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Rankovic Z, Cai J, Kerr J, Fradera X, Robinson J, Mistry A, Finlay W, McGarry G, Andrews F, Caulfield W, Cumming I, Dempster M, Waller J, Arbuckle W, Anderson M, Martin I, Mitchell A, Long C, Baugh M, Westwood P, Kinghorn E, Jones P, Uitdehaag JC, van Zeeland M, Potin D, Saniere L, Fouquet A, Chevallier F, Deronzier H, Dorleans C, Nicolai E. Optimisation of 2-cyano-pyrimidine inhibitors of cathepsin K: Improving selectivity over hERG. Bioorg Med Chem Lett. 2010 Aug 24. PMID:20843687 doi:10.1016/j.bmcl.2010.08.101
