Ribonuclease
From Proteopedia
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[[1z7x]] - hRNase I + inhibitor
<br /> | [[1z7x]] - hRNase I + inhibitor
<br /> | ||
[[3ljd]], [[3ln8]], [[2vq8]], [[2vq9]] - ZeRNase I – Zebrafish<br /> | [[3ljd]], [[3ln8]], [[2vq8]], [[2vq9]] - ZeRNase I – Zebrafish<br /> | ||
| - | [[ | + | [[2pqx]], [[2pqy]] - EcRNase I
- ''Escherichia coli''<br /> |
[[2z70]], [[2ea1]] - EcRNAse I + DNA<BR />
| [[2z70]], [[2ea1]] - EcRNAse I + DNA<BR />
| ||
Revision as of 11:13, 31 March 2011
Ribonuclease (RNase) degrades RNA. The endonucleases cleave single or double stranded RNA and include RNase III, A, T1 H and P. Exo-RNases remove terminal nucleotide
from the ends of the RNA molecule. They include RNase II D, T, PH, Polynucleotide Phosphorylase (PNPase) and oligoribonuclease (ORNase).
RNase A cleaves C or U of single-stranded RNA (ssRNA). RNase BA is RNase from Bacillus amyloliquefaciens. RNase D degrades 3'-end pre-tRNA. RNase H cleaves RNA/DNA double-strand to produce ssDNA. RNase I cleaves 3'-end of ssRNA. RNase II degrades 3'-end ssRNA. RNase III cleaves rRNA. RNase P is a ribozyme. RNase S is RNase A cleaved by subtilisin. RNase SA is RNase from Streptomyces auerofaciens. RNase T is involved in RNA maturation. RNase T1 cleaves 3'-end G from ssRNA. RNase U2 cleaves 3'-end A from ssRNA.
3D Structures of Ribonuclease
RNase I
3mwq, 3mwq, 3mx8, 3i67, 3i6f, 3i6h, 3i6j, 3i7w, 3eux, 3euy, 3euz, 3ev0, 3ev1, 3ev2, 3ev3, 3ev4, 3ev5, 3ev6, 3dh5, 2e3w, 2g4w, 2g4x, 2gbq, 2blp, 2blz, 1jvt, 1jvv, 1js0, 1fs3, 1kf2, 1kf3, 1kf4, 1kf5, 1kf7, 1kf8, 1aqp, 1a2w, 1rnw, 1rnz, 1rno, 1rnq, 1rbx, 1ssc, 3srn, 4srn, 1srn, 5rsa - bRNase I pancreatic - bovine
3a1r - bRNase I pancreatic - neutron
3i7x, 3i7y, 3fkz, 3fl3, 3dh6, 3di7, 3di8, 3di9, 3dib, 3dic, 2oqf, 3bcm, 3bco, 3bcp, 2nui, 2op2, 1ymn, 1ymr, 1ymw, 2apq, 1izp, 1izq, 1izr, 1kh8, 1c8w, 1eic, 1eid, 1eie, 1dy5, 3rsd, 3rsk, 1ssa, 1ssb - bRNase I pancreatic (mutant)
3lxo, 3jw1, 3djo, 3djp, 3djq, 3djv, 3djx, 3dxg, 3dxh, 2w5g, 2w5i, 2w5k, 2w5l, 2w5m, 3d6o, 3d6p, 3d6q, 3d7b, 3d8y, 3d8z, 2qca, 2g8r, 1z6d, 1z6s, 1u1b, 1w4o, 1w4p, 1w4q, 1wbu, 1o0f, 1jn4, 1jvu, 1f0v, 1ruv, 1rnm, 1rnn, 1rbw, 1rca, 1rpf, 1rpg, 1rph, 1rbw, 1rca, 1rpf, 1rpg, 1rph, 1rnc, 1rnd, 1rob, 1rta, 1rtb - bRNase I pancreatic + nucleotide
6rsa - bRNase I pancreatic + nucleotide - neutron
3fl0, 3fl1, 4rsk - bRNase I pancreatic (mutant) + nucleotide
2xog, 2xoi, 2q4g, 1dfj - bRNase I pancreatic + inhibitor
1rar, 1ras - bRNase I pancreatic fluorescent
2p42, 2p43, 2p44, 2p45 , 2p46, 2p47, 2p48, 2p49, 2p4a, 1bzq - bRNase I + antibody
3f8g, 2e0j, 2e0l, 2e0m, 2e0o, 1h8x, 1e21, 1dza - hRNase I pancreatic (mutant) - human
2k11 - hRNase I pancreatic]] - NMR
1z7x - hRNase I + inhibitor
3ljd, 3ln8, 2vq8, 2vq9 - ZeRNase I – Zebrafish
2pqx, 2pqy - EcRNase I
- Escherichia coli
2z70, 2ea1 - EcRNAse I + DNA
RNase II
2ix0, 2id0 - EcRNase II
2ix1 - EcRNase II (mutant)
1m58, 1km8, 1km9- BuRNase 2 - Bullfrog
1bc4 - BuRNase 2 - NMR
1m07 - BuRNase 2 + DNA
RNase III
2nue, 2nuf, 2nug, 1yyk, 1yyw - AaRNase III + RNA - Aquifex aeolicus
2ez6, 1yyo, 1yz9, 1rc7 - AaRNase III (mutant) + RNA
1rc5, 1i4s, 1jfz - AaRNase III N-terminal
1z5f - BuRNase III
2a11 - MtRNase III - Mycobacterium tuberculosis
1o0w - TmRNase III - Thermotoga maritima
2kb5 - hRNase 3 - NMR
1dyt, 1qmt - hRNase 3
1h1h - hRNase 3 + nucleotide
RNase 4
1wdy - hRNase 4
2rnf, 1rnf - hRNase 4 + nucleotide
1kvz - BuRNase 4 - NMR
RNase 5
1un3, 1un4, 1un5, 1gv7 - hRNase 5 (mutant)
1h0d - hRNase 5 + antibody
3lje - ZeRNase 5
RNase 7
2hky - hRNase 7 - NMR
RNase A
1rra - RNase A (mutant) – rat
RNase BA
1x1u, 1x1x, 1x1y, 1b27, 1b2u, 1b3s - BaRNase BA + Barstar (mutant) - Bacillus amyloliquefaciens
3da7, 1brs, 1bgs - BaRNase BA + Barstar
1b2s, 2za4 - BaRNase BA (mutant) + Barstar (mutant)
1brn, 2kf5, 2kf6, 1rnb - BaRNase BA + nucleotide
3kch, 2f4y, 2f56, 2f5m, 2f5w - BaRNase BA crosslinked
2kf3, 2kf4, 1fw7, 1bnr - BaRNase BA – NMR
1yvs, 1b2x, 1a2p, 1bni, 1bnj - BaRNase BA
1b20, 1b21, 1b2z, 1bne, 1bnf, 1bng, 1brh, 1bri, 1brj, 1brk, 1bns, 1brg, 1bsa, 1bsb, 1bsc, 1bsd, 1bse, 1ban, 1bao - BaRNase BA (mutant)
RNase D
1yt3 - EcRNase D
RNase E
2vmk, 2c4r, 2bx2 - EcRNase E catalytic domain
1slj - EcRNase E S1 domain - NMR
1smx, 1sn8 - EcRNase E S1 domain
2vrt, 2c0b - EcRNase E catalytic domain + RNA
RNase H
3h7i, 3h8s, 3h8w - T4RNase H (mutant) - Enterobacteria phage T4
2ihn - T4RNase H (mutant) + DNA
3h8j, 1tfr- T4RNase H
2rpi, 1ril - TtRNase H - Thermus thermophilus - NMR
1jl2 - EcRNase H /TtRNase H
3d0p - BhRNase H (mutant) + DNA - Bacillus halodurans
1zbf - BhRNase H (mutant)
2r7y, 2g8f, 2g8h, 2g8i, 2g8k, 2g8u, 2g8v, 2g8w, 1zbi, 1zbl - BhRNase H (mutant) + RNA + DNA
RNase HI
2qk9, 2qkb, 2qkk - hRNase HI (mutant) + RNA + DNA
3h08 - RNase HI - Chlorobaculum tepidum
3aa2, 3aa3, 3aa4, 3aa5, 2yv0, 2z1g, 2z1h, 2z1i, 2z1j, 1wse, 1wsf, 1wsg, 1wsh, 1wsi, 1wsj, 1jxb, 1jl1, 1f21, 1kva, 1kvb, 1kvc, 1goa, 1gob, 1goc - EcRNase HI (mutant)
1g15, 1rdd - EcRNase HI
1rch - EcRNase HI - NMR
2zqb - SoRNase HI (mutant) - Shewanella oneidensis
2e4l - SoRNase HI
3bsu - hRNase HI catalytic domain + RNA + DNA
2ehg - RNase HI - Sulfolobus tokodaii
1qhk - RNase HI N-terminal - yeast – NMR
RNase HII
3p83 - AfRNase HII + DNA polymerase sliding clamp - Archaeoglobus fulgidus
1i39, 1i3a - AfRNAse HII
3puf, 3p56, 3p5j - hRNAse H2 subunits α+β+γ
3kio - mRNase H2 subunits α+β+γ
- mouse
3o3g - TmRNase HII + DNA
3o3f, 3o3h - TmRNase HII (mutant) + DNA
2etj - TmRNase HII
1x1p - TkRNase HII
2dfe, 2dff, 2dfh - TkRNase HII (mutant) - Thermococcus kodakarensis
1eke - RNase HII - Methanocalcococcus jannaschii
2d0a, 2d0b, 2d0c - RNase HIII - Geobacillus stearothermophilus
RNase J
3bk1 - TtRNase J
3bk2 - TtRNase J + nucleotide
RNase LE
1dix - RNase LE - Solanum lycopersicum
RNase MS
1rms - RNase MS + nucleotide - Aspergillus phoenicis
RNase MC1
1v9h, 1j1f, 1j1g - McRNase MC1 (mutant) + nucleotide - Momordica charantia
1ucd - McRNase MC1 + nucleotide
1bk7 - McRNase MC1
RNase NT
1vcz, 1vd1, 1vd3 - RNase NT + nucleotide] - Nicotiana glutinosa
RNase P
3ok7, 3okb - TmRNase P + TmRNase P RNA + tRNA Phe
1nz0 - TmRNase P
1d6t - RNase P - Staphylococcus aureus
2a64 - RNase P (mutant) - Bacillus stearothermophilus
RNase PH
3dd6 - RNase PH - Bacillus anthracis
1oyp, 1oyr, 1oys - RNase PH - Bacillus subtilis
1r6l, 1r6m - PaRNase PH - Pseudomonas aeruginosa
3b4t - MtRNase PH - Mycobacterium tuberculosis
1udn - AaRNase PH
1udo, 1udq, 1uds - AaRNase PH (mutant)
RNase S
3oqy, 3oqz, 3or0, 1z3l, 1z3m, 1z3p, 1y92, 1y94, 1fev, 1d5d, 1d5e, 1d5h, 2rln - bRNase S seminal (mutant)
1tq9, 1r5c - bRNase S + nucleotide
1r5d, 1r3m, 1n1x, 1n3z, 1j7z, 1j80, 1j81, 1j82, 1cjq, 1cjr, 1bsr - bRNase S
RNase S3
1iqq - RNase S3 - Japanese pear
RNase SA
3a5e, 1zgx, 1ynv, 1t2h, 1t2i, 1uci, 1ucj, 1uck, 1ucl, 1i70, 1i8v, 1box - SaRNase SA guanyl-specific (mutant) - Streptomyces aureofaciens
1lni - SaRNase SA
1gmp, 1gmq, 1gmr - SaRNase SA +nucleotide
1ay7 - SaRNase SA + Barstar
1rsn - SaRNase SA + cyclophosphothiolate
RNase SA2
3dgy, 3dh2, 3d4a, 3d5g, 3d5i - SaRNase SA2 + mononucleotide
RNase SA3
RNase SF11
1ioo - RNase SF11 - Nicotiana alata
RNase T
2is3 - EcRNase T
2f96 - PaRNase T
RNase T1
1tto - AoRNase T1 - Aspergillus oryzae
1q9e, 1iyy, 1i2e, 1i2f, 1i2g, 1i3f, 1i3i, 1hz1, 1fys, 1fzu, 1ch0, 4bir, 3bir, 5bir - AoRNase T1 (mutant)
1lov, 1low, 1loy, 1i0v, 1i0x, 1b2m, 1rhl, 1bir, 1rgk, 1rgl - AoRNase T1 (mutant) + nucleotide
1bvi, 2bu4, 2hoh, 4hoh, 5hoh, 3hoh, 2gsp, 3gsp, 4gsp, 5gsp, 6gsp, 7gsp, 1gsp, 1det, 1rls, 1lra, 1rga - AoRNase T1 + nucleotide
1ygw - AoRNase T1 – NMR
RNase U2
3agn, 3ago, 3ahw - UsRNase U2 + AMP - Ustilago sphaerogena
1rtu - UsRNase U2
RNase U2B
3ahs - UsRNase U2B
RNase Z
2e7y - TmRNase Z
2fk6 - BsRNase Z (mutant) + tRNA Thr
1y44 - BsRNase Z (mutant)
Oligoribonuclease
2igi, 1yta – EcORNase
2gbz - ORNase - Xanthomonas campestris
1j9a - ORNase - Haemophilus influenzae
Polynucleotide Phosphorylase
3cdi - EcPNPase
3gll - EcPNPase core
3cdj - EcPNPase C-terminal truncated
1e3h, 1e3p - PNPase - Streptomyces antibioticus
3gcm, 3gme, 3h1c - EcPNPase + RNase E recognition domain
3h36 - PNPase fragment - Streptococcus mutans
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Wayne Decatur, David Canner, Joel L. Sussman, Jaime Prilusky
