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=Chorismate Mutase=
=Chorismate Mutase=
==Introduction==
==Introduction==
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Chorismate mutase is an essential enzyme in the shikimate pathway<ref name="pizza" />. This pathway allows for the biosynthesis of aromatic amino acids tryptophan, tyrosine, and phenylalanine <ref name="pizza" />. The production of tyrosine and phenylalanine is achieved by what is called a Claisen arrangement. first converting chorismate to prephenate. Prephenate then reacts with prephenate dehydratase and prephenate dehydrogenase which forms phenylpyruvate and hydroxyphenylpyruvate. After this occursm aminotransferase converts hydroxy-phenylpyruvate and phenylpyruvate to phenylalanine and tyrosine. Chorismate mutase provides a 2x10<sup>6</sup>
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Chorismate mutase is an essential enzyme in the shikimate pathway<ref name="pizza" />. This pathway allows for the biosynthesis of aromatic amino acids tryptophan, tyrosine, and phenylalanine <ref name="pizza" />. The production of tyrosine and phenylalanine is achieved by what is called a Claisen arrangement. first converting chorismate to prephenate. Prephenate then reacts with prephenate dehydratase and prephenate dehydrogenase which forms phenylpyruvate and hydroxyphenylpyruvate. After this occursm aminotransferase converts hydroxy-phenylpyruvate and phenylpyruvate to phenylalanine and tyrosine. Chorismate mutase provides a 2x10<sup>6</sup> fold increase in the rate of reaction, in comparison to the uncatalyzed reaction

Revision as of 20:56, 1 April 2011

PDB ID 2f6l

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2f6l, resolution 1.70Å ()
Gene: Rv1885c (Mycobacterium tuberculosis)
Activity: Chorismate mutase, with EC number 5.4.99.5
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml


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Contents

Chorismate Mutase

Introduction

Chorismate mutase is an essential enzyme in the shikimate pathway[1]. This pathway allows for the biosynthesis of aromatic amino acids tryptophan, tyrosine, and phenylalanine [1]. The production of tyrosine and phenylalanine is achieved by what is called a Claisen arrangement. first converting chorismate to prephenate. Prephenate then reacts with prephenate dehydratase and prephenate dehydrogenase which forms phenylpyruvate and hydroxyphenylpyruvate. After this occursm aminotransferase converts hydroxy-phenylpyruvate and phenylpyruvate to phenylalanine and tyrosine. Chorismate mutase provides a 2x106 fold increase in the rate of reaction, in comparison to the uncatalyzed reaction


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Section b

I like pizza [1] blah blah blah[1]

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References

  1. ↑ 1.0 1.1 1.2 1.3 Kim SK, Reddy SK, Nelson BC, Vasquez GB, Davis A, Howard AJ, Patterson S, Gilliland GL, Ladner JE, Reddy PT. Biochemical and structural characterization of the secreted chorismate mutase (Rv1885c) from Mycobacterium tuberculosis H37Rv: an *AroQ enzyme not regulated by the aromatic amino acids. J Bacteriol. 2006 Dec;188(24):8638-48. PMID:17146044 doi:188/24/8638
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