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Sandbox Reserved 342

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=Introduction=
=Introduction=
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Xanthine-guanine Phosphoribosyltansferase (XGPRT) is one of three PRTases that are part of the purine salvage pathway in Escherichia coli <ref name="Vos"> PMID:9743633 </ref>.
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Xanthine-guanine Phosphoribosyltansferase (XGPRT) is one of three purine phosphoribosyltransferases (PRTases) that are part of the purine salvage pathway in Escherichia coli <ref name="Vos"> PMID:9743633 </ref>; the other two PRTases in the pathway are HPRT and APRT<ref name="Vos"/>.
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=STRUCTURE=
=STRUCTURE=
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==FEATURES==
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<scene name='Sandbox_Reserved_342/Trial/1'>TextToBeDisplayed</scene>
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=FUNCTION=
=FUNCTION=
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XGRT is an enzyme that catalyzes the conversion of guanine, xanthine, and sometimes hypoxanthine, to GMP, XMP, and IMP <ref name="Vos"/>.
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The RCSB <ref name="Vos"/>
 
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=MECHANISM=
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<scene name='Sandbox_Reserved_342/Trial/1'>TextToBeDisplayed</scene>=MECHANISM=
==RECOGNITION==
==RECOGNITION==
==CATALYSIS==
==CATALYSIS==
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Magnesium and other divalent cations are necessary for catalysis<ref name="Vos"/>.
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=IMPORTANCE=
=IMPORTANCE=
<Structure load='1a96' size='300' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />
<Structure load='1a96' size='300' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />

Revision as of 00:56, 3 April 2011

This Sandbox is Reserved from January 10, 2010, through April 10, 2011 for use in BCMB 307-Proteins course taught by Andrea Gorrell at the University of Northern British Columbia, Prince George, BC, Canada.
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  • Click the 3D button (when editing, above the wikitext box) to insert Jmol.
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More help: Help:Editing

PDB ID 1a96

Drag the structure with the mouse to rotate
1a96, resolution 2.00Å ()
Ligands: , , ,
Gene: GPT (Escherichia coli)
Activity: Xanthine phosphoribosyltransferase, with EC number 2.4.2.22
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml




Xanthine-guanine Phosphoribosyltransferase

Contents

Introduction

Xanthine-guanine Phosphoribosyltansferase (XGPRT) is one of three purine phosphoribosyltransferases (PRTases) that are part of the purine salvage pathway in Escherichia coli [1]; the other two PRTases in the pathway are HPRT and APRT[1].


STRUCTURE

FUNCTION

XGRT is an enzyme that catalyzes the conversion of guanine, xanthine, and sometimes hypoxanthine, to GMP, XMP, and IMP [1].


=MECHANISM=

RECOGNITION

CATALYSIS

Magnesium and other divalent cations are necessary for catalysis[1].

IMPORTANCE

Insert caption here

Drag the structure with the mouse to rotate

ADDITIONAL RESOURCES

References

  1. ↑ 1.0 1.1 1.2 1.3 Vos S, Parry RJ, Burns MR, de Jersey J, Martin JL. Structures of free and complexed forms of Escherichia coli xanthine-guanine phosphoribosyltransferase. J Mol Biol. 1998 Oct 2;282(4):875-89. PMID:9743633 doi:10.1006/jmbi.1998.2051
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