Sandbox Reserved 317

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{{STRUCTURE_1bzy | PDB=1bzy | SCENE=Sandbox_Reserved_317/Scene_1/1}}
{{STRUCTURE_1bzy | PDB=1bzy | SCENE=Sandbox_Reserved_317/Scene_1/1}}
=Introduction=
=Introduction=
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Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) is a key enzyme in purine salvage pathways. This enzyme salvages guanine directly and adenine indirectly from catabolism. It catalyzes the reversible transfer of the phosphoribosyl group from a-D-5-phosphoribosyl 1-pyrophosphate (PRPP) to hypoxanthine or guanine forming either IMP or GMP, respectively. This reaction is dependent on a divalent magnesium cation. HGPRT is deficient in Lesch-Nyhan syndrome, a sever neurological disorder characterized by high levels of blood uric acid and uncontrollable self mutilation. A partial deficiency of the enzyme leads to gouty arthritis.
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Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) is a key enzyme in purine salvage pathways. This enzyme salvages guanine directly and adenine indirectly from catabolism. It catalyzes the reversible transfer of the phosphoribosyl group from a-D-5-phosphoribosyl 1-pyrophosphate (PRPP) to hypoxanthine or guanine forming either IMP or GMP, respectively. This reaction is dependent on a divalent magnesium cation. HGPRT is deficient in Lesch-Nyhan syndrome, a sever neurological disorder characterized by high levels of blood uric acid and uncontrollable self mutilation. A partial deficiency of the enzyme leads to gouty arthritis <ref name="Shi"> PMID:10360366 </ref>
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<ref name="Shi"> PMID:10360366 </ref>
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<scene name='Sandbox_Reserved_317/Scene_1/1'>TextToBeDisplayed</scene>
<scene name='Sandbox_Reserved_317/Scene_1/1'>TextToBeDisplayed</scene>

Revision as of 01:32, 4 April 2011

This Sandbox is Reserved from January 10, 2010, through April 10, 2011 for use in BCMB 307-Proteins course taught by Andrea Gorrell at the University of Northern British Columbia, Prince George, BC, Canada.
To get started:
  • Click the edit this page tab at the top. Save the page after each step, then edit it again.
  • Click the 3D button (when editing, above the wikitext box) to insert Jmol.
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More help: Help:Editing

PDB ID 1bzy

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1bzy, resolution 2.00Å ()
Ligands: , ,
Activity: Hypoxanthine phosphoribosyltransferase, with EC number 2.4.2.8
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml


Contents

Introduction

Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) is a key enzyme in purine salvage pathways. This enzyme salvages guanine directly and adenine indirectly from catabolism. It catalyzes the reversible transfer of the phosphoribosyl group from a-D-5-phosphoribosyl 1-pyrophosphate (PRPP) to hypoxanthine or guanine forming either IMP or GMP, respectively. This reaction is dependent on a divalent magnesium cation. HGPRT is deficient in Lesch-Nyhan syndrome, a sever neurological disorder characterized by high levels of blood uric acid and uncontrollable self mutilation. A partial deficiency of the enzyme leads to gouty arthritis [1]

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Section 1.1

jjhjh RCSB Protein Data Bank [1]

Section 1.2

Text to display

References

  1. ↑ 1.0 1.1 Shi W, Li CM, Tyler PC, Furneaux RH, Grubmeyer C, Schramm VL, Almo SC. The 2.0 A structure of human hypoxanthine-guanine phosphoribosyltransferase in complex with a transition-state analog inhibitor. Nat Struct Biol. 1999 Jun;6(6):588-93. PMID:10360366 doi:http://dx.doi.org/10.1038/9376
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